| Issue |
Med Sci (Paris)
Volume 32, Number 11, Novembre 2016
Le microbiote : cet inconnu qui réside en nous
|
|
|---|---|---|
| Page(s) | 1035 - 1037 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/20163211024 | |
| Published online | 23 December 2016 | |
Les débuts de CRISPR en thérapie génique
Chroniques génomiques
First use of CRISPR for gene therapy
1
UMR 7268 ADÉS, Aix-Marseille, Université/ EFS/CNRS,Espace éthique méditerranéen, hôpital d’adultes la Timone, 264, rue Saint-Pierre, 13385
Marseille Cedex 05, France
2
CoReBio PACA, case 901, parc scientifique de Luminy, 13288 Marseille Cedex 09, France
*
bertrand.jordan@univ-amu.fr ; brjordan@orange.fr
Abstract
Two clinical trials using CRISPR technology to engineer the T cells of cancer patients by inactivating the gene for immune checkpoint molecule PD-1 are (almost) underway, one in the USA and the other in China. The less sophisticated Chinese trial seems slated to begin first, in part because of very speedy approval ; it may however trigger autoimmune reactions that could be very serious.
© 2016 médecine/sciences – Inserm
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