Issue |
Med Sci (Paris)
Volume 25, Number 6-7, Juin-Juillet 2009
|
|
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Page(s) | 601 - 607 | |
Section | Dossier Biologie des systèmes | |
DOI | https://doi.org/10.1051/medsci/2009256-7601 | |
Published online | 15 June 2009 |
Biologie des systèmes appliqués aux cancers
Systems biology of cancer
Institut Curie, 26, rue d’Ulm, F-75248 Paris Cedex 05
Inserm, U900, F-75248 Paris
École des Mines ParisTech, F-75248 Paris, France
La biologie des systèmes appliqués aux cancers est aujourd’hui une approche scientifique reconnue et porteuse d’espoirs dans les domaines cliniques. Elle s’appuie sur une formalisation rigoureuse des réseaux de régulation en des langages complets et non ambigus. Elle donne du système étudié (un réseau d’interactions gouvernant la prolifération, la différenciation ou la mort cellulaires) une vue détaillée mais aussi une décomposition modulaire qui facilite l’interprétation des profils moléculaires de tumeurs. Ces modèles mathématiques permettent de prédire l’évolution du système, en particulier de proposer des points d’intervention pour le développement de médicaments, anticiper l’évolution tumorale et classifier les tumeurs.
Abstract
Cancer Systems Biology is now accepted and recognized as a promising field both in biological and clinical research. It relies on a rigorous formalization of regulation networks into precise and unambiguous languages. It provides both detailed and modular views of the complex biological system of interest (which in cancer research is typically an interaction network governing essential cellular events such as proliferation, differentiation, cell death…) in order to facilitate the interpretation of molecular profiles of tumors. The translation of these networks into mathematical models allows prediction of the evolution of the system in time and under certain perturbations. As a result, it can not only propose specific target points for pharmaceutical purposes, but also anticipate the evolution of tumors as well as their classifications. These characteristics emphasize the important role of Systems Biology of Cancer in the future of biomedical research.
© 2009 médecine/sciences - Inserm / SRMS
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