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Home All issues Volume 34 (October 2018) Focus issue F1 Med Sci (Paris), 34 (2018) 99-104 References
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Issue
Med Sci (Paris)
Volume 34, October 2018
Cancer biomarkers
Page(s) 99 - 104
DOI https://doi.org/10.1051/medsci/201834f117
Published online 07 November 2018
  1. Haggar FA Boushey RP Colorectal cancer epidemiology: Incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg 2009 ; 22 : 191–197. [CrossRef] [Google Scholar]
  2. Arnold M Sierra MS Laversanne M Soerjomataram I Jemal A Bray F Global patterns and trends in colorectal cancer incidence and mortality. Gut 2017 ; 66 : 683–691. [CrossRef] [PubMed] [Google Scholar]
  3. Gonzalez M Robert JH Halkic N Mentha G Roth A Perneger T Ris HB Gervaz P Survival after lung metastasectomy in colorectal cancer patients with previously resected liver metastases. World J Surg 2012 ; 36 : 386–391. [CrossRef] [PubMed] [Google Scholar]
  4. Beck JT Ismail A Tolomeo C Targeting the phosphatidylinositol 3-kinase (pi3k)/akt/mammalian target of rapamycin (mtor) pathway: An emerging treatment strategy for squamous cell lung carcinoma. Cancer Treat Rev 2014 ; 40 : 980–989. [CrossRef] [PubMed] [Google Scholar]
  5. Papadimitrakopoulou V. Development of pi3k/akt/mtor pathway inhibitors and their application in personalized therapy for non-small-cell lung cancer. J Thorac Oncol 2012 ; 7 : 1315–1326. [CrossRef] [Google Scholar]
  6. Huang J Manning BD The tsc1-tsc2 complex: A molecular switchboard controlling cell growth. Biochem J 2008 ; 412 : 179–190. [CrossRef] [PubMed] [Google Scholar]
  7. Hoogeveen-Westerveld M van Unen L van den Ouweland A Halley D Hoogeveen A Nellist M The tsc1-tsc2 complex consists of multiple tsc1 and tsc2 subunits. BMC Biochem 2012 ; 13 : 18. [CrossRef] [PubMed] [Google Scholar]
  8. Li Y Inoki K Vikis H Guan KL Measurements of tsc2 gap activity toward rheb. Methods Enzymol 2006 ; 407 : 46–54. [CrossRef] [PubMed] [Google Scholar]
  9. Li Y Inoki K Guan KL Biochemical and functional characterizations of small gtpase rheb and tsc2 gap activity. Mol Cell Biol 2004 ; 24 : 7965–7975. [CrossRef] [PubMed] [Google Scholar]
  10. Inoki K Li Y Xu T Guan KL Rheb gtpase is a direct target of tsc2 gap activity and regulates mtor signaling. Genes Dev 2003 ; 17 : 1829–1834. [CrossRef] [PubMed] [Google Scholar]
  11. Parmar N Tamanoi F Rheb g-proteins and the activation of mtorc1. Enzymes 2010 ; 27 : 39–56. [CrossRef] [Google Scholar]
  12. Sato T Nakashima A Guo L Tamanoi F Specific activation of mtorc1 by rheb g-protein in vitro involves enhanced recruitment of its substrate protein. J Biol Chem 2009 ; 284 : 12783–12791. [CrossRef] [PubMed] [Google Scholar]
  13. Lee JT Lehmann BD Terrian DM Chappell WH Stivala F Libra M Martelli AM Steelman LS McCubrey JA Targeting prostate cancer based on signal transduction and cell cycle pathways. Cell Cycle 2008 ; 7 : 1745–1762. [CrossRef] [PubMed] [Google Scholar]
  14. Chang F Lee JT Navolanic PM Steelman LS Shelton JG Blalock WL Franklin RA McCubrey JA Involvement of pi3k/akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy. Leukemia 2003 ; 17 : 590–603. [CrossRef] [PubMed] [Google Scholar]
  15. Miled N Yan Y Hon WC Perisic O Zvelebil M Inbar Y Schneidman-Duhovny D Wolfson HJ Backer JM Williams RL Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 2007 ; 317 : 239–242. [CrossRef] [Google Scholar]
  16. Song MS, Salmena L, Pandolfi PP. The functions and regulation of the pten tumour suppressor. Nat Rev Mol Cell Biol 2012;13:283–296. [CrossRef] [PubMed] [Google Scholar]
  17. Huang WC Hung MC Beyond nf-kappab activation: Nuclear functions of ikappab kinase alpha. J Biomed Sci 2013 ; 20 : 3. [CrossRef] [PubMed] [Google Scholar]
  18. Ruvolo PP Deng X May WS Phosphorylation of bcl2 and regulation of apoptosis. Leukemia 2001 ; 15 : 515–522. [CrossRef] [PubMed] [Google Scholar]
  19. Carnero A Blanco-Aparicio C Renner O Link W Leal JF The pten/pi3k/akt signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 2008 ; 8 : 187–198. [CrossRef] [PubMed] [Google Scholar]
  20. McNamara CR Degterev A Small-molecule inhibitors of the pi3k signaling network. Future Med Chem 2011 ; 3 : 549–565. [CrossRef] [PubMed] [Google Scholar]
  21. Geuna E Milani A Martinello R Aversa C Valabrega G Scaltriti M Montemurro F Buparlisib, an oral pan-pi3k inhibitor for the treatment of breast cancer. Expert Opin Investig Drugs 2015 ; 24 : 421–431. [CrossRef] [PubMed] [Google Scholar]
  22. Malkomes P Lunger I Luetticke A Oppermann E Haetscher N Serve H Holzer K Bechstein WO Rieger MA Selective akt inhibition by mk-2206 represses colorectal cancer-initiating stem cells. Ann Surg Oncol 2016 ; 23 : 2849–2857. [CrossRef] [PubMed] [Google Scholar]
  23. Hurez V Dao V Liu A Pandeswara S Gelfond J Sun L Bergman M Orihuela CJ Galvan V Padron A Drerup J Liu Y Hasty P Sharp ZD Curiel TJ Chronic mtor inhibition in mice with rapamycin alters t, b, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice. Aging Cell 2015 ; 14 : 945–956. [CrossRef] [PubMed] [Google Scholar]
  24. Wang H Zhang L Yang X Jin Y Pei S Zhang D Zhang H Zhou B Zhang Y Lin D Puma mediates the combinational therapy of 5-fu and nvp-bez235 in colon cancer. Oncotarget 2015 ; 6 : 14385–14398. [PubMed] [Google Scholar]
  25. Zhu L Ding X Zhu X Meng S Wang J Zhou H Duan Q Tao J Schifferli DM Zhu G Biphasic activation of pi3k/akt and mapk/erk1/2 signaling pathways in bovine herpesvirus type 1 infection of mdbk cells. Vet Res 2011 ; 42 : 57. [CrossRef] [PubMed] [Google Scholar]
  26. Martelli AM Evangelisti C Follo MY Ramazzotti G Fini M Giardino R Manzoli L McCubrey JA Cocco L Targeting the phosphatidylinositol 3-kinase/akt/mammalian target of rapamycin signaling network in cancer stem cells. Curr Med Chem 2011 ; 18 : 2715–2726. [CrossRef] [PubMed] [Google Scholar]
  27. Mijatovic T Mahieu T Bruyere C De Neve N Dewelle J Simon G Dehoux MJ van der Aar E Haibe-Kains B Bontempi G Decaestecker C Van Quaquebeke E Darro F Kiss R Unbs5162, a novel naphthalimide that decreases cxcl chemokine expression in experimental prostate cancers. Neoplasia 2008 ; 10 : 573–586. [CrossRef] [Google Scholar]

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