Diversification post-traductionnelle de la spécificité des immunoglobulines

Cyril Planchais; Nimesh Gupta; Srinivas V. Kaveri; Sébastien Lacroix-Desmazes; Jordan D. Dimitrov

doi:10.1051/medsci/20132911002

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Volume 29 / Numéro 11 (Novembre 2013)

Med Sci (Paris), 29 11 (2013) 937-940

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Numéro		Med Sci (Paris) Volume 29, Numéro 11, Novembre 2013


Page(s)		937 - 940
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/20132911002
Publié en ligne		20 novembre 2013

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Balla J, Jacob HS, Balla G, et al. Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci USA 1993 ; 90 : 9285–9289. [CrossRef] [Google Scholar]
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[1] Paul WE. Fundamental immunology. Philadelphia : Lippincott-Williams and Wilkins, 2012. [Google Scholar]

[2] Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996 ; 381 : 751–758. [CrossRef] [PubMed] [Google Scholar]

[3] Manivel V, Bayiroglu F, Siddiqui Z, et al. The primary antibody repertoire represents a linked network of degenerate antigen specificities. J Immunol 2002 ; 169 : 888–897. [PubMed] [Google Scholar]

[4] Notkins AL. Polyreactivity of antibody molecules. Trends Immunol 2004 ; 25 : 174–179. [CrossRef] [PubMed] [Google Scholar]

[5] Dimitrov JD, Roumenina LT, Doltchinkova VR, et al. Antibodies use heme as a cofactor to extend their pathogen elimination activity and to acquire new effector functions. J Biol Chem 2007 ; 282 : 26696–26706. [CrossRef] [PubMed] [Google Scholar]

[6] Baker H, Frank O, Feingold S, Leevy CM. Vitamin distribution in human plasma proteins. Nature 1967 ; 215 : 84–85. [CrossRef] [PubMed] [Google Scholar]

[7] McEnaney PJ, Parker CG, Zhang AX, Spiegel DA. Antibody-recruiting molecules: an emerging paradigm for engaging immune function in treating human disease. ACS Chem Biol 2012 ; 7 : 1139–1151. [CrossRef] [PubMed] [Google Scholar]

[8] Dimitrov JD, Vassilev TL, Cofactor-mediated protein promiscuity. Nat Biotechnol 2009 ; 27 : 892. [CrossRef] [Google Scholar]

[9] Balla J, Jacob HS, Balla G, et al. Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci USA 1993 ; 90 : 9285–9289. [CrossRef] [Google Scholar]

[10] Wardemann H, Yurasov S, Schaefer A, et al. Predominant autoantibody production by early human B cell precursors. Science 2003 ; 301 : 1374–1377. [CrossRef] [PubMed] [Google Scholar]