Un trio de choc pour pallier la chimiorésistance des cancers : c-MYC, PARP1, BIN1

Slovénie Pyndiah; Daitoku Sakamuro

doi:10.1051/medsci/2013292006

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Volume 29 / Numéro 2 (Février 2013)

Med Sci (Paris), 29 2 (2013) 133-135

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Numéro		Med Sci (Paris) Volume 29, Numéro 2, Février 2013


Page(s)		133 - 135
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/2013292006
Publié en ligne		28 février 2013

Goda K, Bacsó Z, Szabó Z. Multidrug resistance through the spectacle of P-glycoprotein. Curr Cancer Drug Targets 2009 ; 9 : 281–297. [CrossRef] [PubMed] [Google Scholar]
Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005 ; 434 : 913–917. [CrossRef] [PubMed] [Google Scholar]
Helleday T, Bryant HE, Schultz N. Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy. Cell Cycle 2005 ; 4 : 1176–1178. [CrossRef] [PubMed] [Google Scholar]
Wechsler-Reya R, Sakamuro D, Zhang J, et al. Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. J Biol Chem 1997 ; 272 : 31453–31458. [CrossRef] [PubMed] [Google Scholar]
Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet 1996 ; 14 : 69–77. [CrossRef] [PubMed] [Google Scholar]
Ghaneie A, Zemba-Palko V, Itoh H, et al. Prendergast, Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival. Cancer Biol Ther 2007 ; 6 : 192–194. [CrossRef] [PubMed] [Google Scholar]
Pyndiah S, Tanida S, Ahmed KM, et al. C-MYC supresses BIN1 to release poly(ADP-ribose) polymerase 1: a mechanism by which cancer cells acquire cisplatin resistance. Sci Signal 2011 ; 4 : ra19. [CrossRef] [PubMed] [Google Scholar]
Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005 ; 434 : 913–917. [CrossRef] [PubMed] [Google Scholar]
Ji Y, Tulin AV. The roles of PARP1 in gene control and cell differentiation. Curr Opin Genet Dev 2010 ; 20 : 512–518. [CrossRef] [PubMed] [Google Scholar]
Sklar MD, Prochownik EV. Modulation of cis-platinum resistance in Friend erythroleukemia cells by c-myc. Cancer Res 1991 ; 51 : 2118–2123. [PubMed] [Google Scholar]
Ramalingam A, Farmer GE, Stamato TD, Prendergast GC. Bin1 interacts with and restrains the DNA end-binding protein complex Ku. Cell Cycle 2007 ; 6 : 1914–1918. [CrossRef] [PubMed] [Google Scholar]
Cassimere EK, Pyndiah S, Sakamuro D. The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage. Cell Death Differ 2009 ; 16 : 1641–1653. [CrossRef] [PubMed] [Google Scholar]
O’Shaughnessy J, Osborne C, Pippen JE, et al. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med 2011 ; 364 : 205–214. [CrossRef] [PubMed] [Google Scholar]

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[1] Goda K, Bacsó Z, Szabó Z. Multidrug resistance through the spectacle of P-glycoprotein. Curr Cancer Drug Targets 2009 ; 9 : 281–297. [CrossRef] [PubMed] [Google Scholar]

[2] Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005 ; 434 : 913–917. [CrossRef] [PubMed] [Google Scholar]

[3] Helleday T, Bryant HE, Schultz N. Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy. Cell Cycle 2005 ; 4 : 1176–1178. [CrossRef] [PubMed] [Google Scholar]

[4] Wechsler-Reya R, Sakamuro D, Zhang J, et al. Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. J Biol Chem 1997 ; 272 : 31453–31458. [CrossRef] [PubMed] [Google Scholar]

[5] Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet 1996 ; 14 : 69–77. [CrossRef] [PubMed] [Google Scholar]

[6] Ghaneie A, Zemba-Palko V, Itoh H, et al. Prendergast, Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival. Cancer Biol Ther 2007 ; 6 : 192–194. [CrossRef] [PubMed] [Google Scholar]

[7] Pyndiah S, Tanida S, Ahmed KM, et al. C-MYC supresses BIN1 to release poly(ADP-ribose) polymerase 1: a mechanism by which cancer cells acquire cisplatin resistance. Sci Signal 2011 ; 4 : ra19. [CrossRef] [PubMed] [Google Scholar]

[8] Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005 ; 434 : 913–917. [CrossRef] [PubMed] [Google Scholar]

[9] Ji Y, Tulin AV. The roles of PARP1 in gene control and cell differentiation. Curr Opin Genet Dev 2010 ; 20 : 512–518. [CrossRef] [PubMed] [Google Scholar]

[10] Sklar MD, Prochownik EV. Modulation of cis-platinum resistance in Friend erythroleukemia cells by c-myc. Cancer Res 1991 ; 51 : 2118–2123. [PubMed] [Google Scholar]

[11] Ramalingam A, Farmer GE, Stamato TD, Prendergast GC. Bin1 interacts with and restrains the DNA end-binding protein complex Ku. Cell Cycle 2007 ; 6 : 1914–1918. [CrossRef] [PubMed] [Google Scholar]

[12] Cassimere EK, Pyndiah S, Sakamuro D. The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage. Cell Death Differ 2009 ; 16 : 1641–1653. [CrossRef] [PubMed] [Google Scholar]

[13] O’Shaughnessy J, Osborne C, Pippen JE, et al. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med 2011 ; 364 : 205–214. [CrossRef] [PubMed] [Google Scholar]