Mécanisme d’action des oncogènes à homéodomaine TLX dans les LAL-T

Vahid Asnafi; Pierre Ferrier

doi:10.1051/medsci/2012288012

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Volume 28 / Numéro 8-9 (Août–Septembre 2012)

Med Sci (Paris), 28 8-9 (2012) 708-710

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Numéro		Med Sci (Paris) Volume 28, Numéro 8-9, Août–Septembre 2012


Page(s)		708 - 710
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/2012288012
Publié en ligne		22 août 2012

Asnafi V, Beldjord K, Boulanger E, et al. Analysis of TCR, pT alpha, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment. Blood 2003 ; 101 : 2693–2703. [CrossRef] [PubMed] [Google Scholar]
Ferrando A, Neuberg D, Dodge RK, et al. Adult T-cell ALL, patients whose lymphoblasts express the HOX11 oncogene have an excellent prognosis when treated with chemotherapy, are not candidates for allogeneic bone marrow transplantaton in first remission. Blood 2004 ; 100 : 154a. [Google Scholar]
Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet 2008 ; 371 : 1030–1043. [CrossRef] [PubMed] [Google Scholar]
Aifantis I, Raetz E, Buonamici S. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol 2008 ; 8 : 380–390. [CrossRef] [PubMed] [Google Scholar]
Argiropoulos B, Humphries RK. Hox genes in hematopoiesis and leukemogenesis. Oncogene 2007 ; 26 : 6766–6776. [CrossRef] [PubMed] [Google Scholar]
Asnafi V, Beldjord K, Libura M, et al. Age-related phenotypic and oncogenic differences in T-cell acute lymphoblastic leukemias may reflect thymic atrophy. Blood 2004 ; 104 : 4173–4180. [CrossRef] [PubMed] [Google Scholar]
Dik WA, Pike-Overzet K, Weerkamp F, et al. New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J Exp Med 2005 ; 201 : 1715–1723. [CrossRef] [PubMed] [Google Scholar]
Giese K, Kingsley C, Kirshner JR, Grosschedl R. Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev 1995 ; 9 : 995–1008. [CrossRef] [PubMed] [Google Scholar]
Dadi S, Le Noir S, Payet-Bornet D, et al. TLX Homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression. Cancer Cell 2012 ; 21 : 563–576. [CrossRef] [PubMed] [Google Scholar]
Ji Y, Resch W, Corbett E, et al. The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell 2010 ; 141 : 419–431. [CrossRef] [PubMed] [Google Scholar]

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[1] Asnafi V, Beldjord K, Boulanger E, et al. Analysis of TCR, pT alpha, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment. Blood 2003 ; 101 : 2693–2703. [CrossRef] [PubMed] [Google Scholar]

[2] Ferrando A, Neuberg D, Dodge RK, et al. Adult T-cell ALL, patients whose lymphoblasts express the HOX11 oncogene have an excellent prognosis when treated with chemotherapy, are not candidates for allogeneic bone marrow transplantaton in first remission. Blood 2004 ; 100 : 154a. [Google Scholar]

[3] Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet 2008 ; 371 : 1030–1043. [CrossRef] [PubMed] [Google Scholar]

[4] Aifantis I, Raetz E, Buonamici S. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol 2008 ; 8 : 380–390. [CrossRef] [PubMed] [Google Scholar]

[5] Argiropoulos B, Humphries RK. Hox genes in hematopoiesis and leukemogenesis. Oncogene 2007 ; 26 : 6766–6776. [CrossRef] [PubMed] [Google Scholar]

[6] Asnafi V, Beldjord K, Libura M, et al. Age-related phenotypic and oncogenic differences in T-cell acute lymphoblastic leukemias may reflect thymic atrophy. Blood 2004 ; 104 : 4173–4180. [CrossRef] [PubMed] [Google Scholar]

[7] Dik WA, Pike-Overzet K, Weerkamp F, et al. New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J Exp Med 2005 ; 201 : 1715–1723. [CrossRef] [PubMed] [Google Scholar]

[8] Giese K, Kingsley C, Kirshner JR, Grosschedl R. Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev 1995 ; 9 : 995–1008. [CrossRef] [PubMed] [Google Scholar]

[9] Dadi S, Le Noir S, Payet-Bornet D, et al. TLX Homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression. Cancer Cell 2012 ; 21 : 563–576. [CrossRef] [PubMed] [Google Scholar]

[10] Ji Y, Resch W, Corbett E, et al. The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell 2010 ; 141 : 419–431. [CrossRef] [PubMed] [Google Scholar]