Cellules épithéliales médullaires thymiques exprimant Aire - Acteurs clés dans l’induction de la tolérance des cellules T

Magali Irla

doi:10.1051/medsci/2012282010

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Volume 28 / Numéro 2 (Février 2012)

Med Sci (Paris), 28 2 (2012) 146-149

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Numéro		Med Sci (Paris) Volume 28, Numéro 2, Février 2012


Page(s)		146 - 149
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/2012282010
Publié en ligne		27 février 2012

Derbinski J, Schulte A, Kyewski B, Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol 2001 ; 2 : 1032–1039. [CrossRef] [PubMed] [Google Scholar]
Klein L, Hinterberger M, von Rohrscheidt J, Aichinger M. Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance. Trends Immunol 2011 ; 32 : 188–193. [CrossRef] [PubMed] [Google Scholar]
Surh CD, Ernst B, Sprent J. Growth of epithelial cells in the thymic medulla is under the control of mature T cells. J Exp Med 1992 ; 176 : 611–616. [CrossRef] [PubMed] [Google Scholar]
Hikosaka Y, Nitta T, Ohigashi I, et al. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 2008 ; 29 : 438–450. [CrossRef] [PubMed] [Google Scholar]
Irla M, Hugues S, Gill J, et al. Autoantigen-specific interactions with CD4⁺ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity 2008 ; 29 : 451–463. [CrossRef] [PubMed] [Google Scholar]
Irla M, Hollander G, Reith W. Control of central self-tolerance induction by autoreactive CD4⁺ thymocytes. Trends Immunol 2010 ; 31 : 71–79. [CrossRef] [PubMed] [Google Scholar]
Boehm T, Scheu S, Pfeffer K, Bleul CC. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J Exp Med 2003 ; 198 : 757–769. [CrossRef] [PubMed] [Google Scholar]
Akiyama T, Shimo Y, Yanai H, et al. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity 2008 ; 29 : 423–437. [CrossRef] [PubMed] [Google Scholar]
Rossi SW, Kim MY, Leibbrandt A, et al. RANK signals from CD4⁺3⁻ inducer cells regulate development of aire-expressing epithelial cells in the thymic medulla. J Exp Med 2007 ; 204 : 1267–1272. [CrossRef] [PubMed] [Google Scholar]

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[1] Derbinski J, Schulte A, Kyewski B, Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol 2001 ; 2 : 1032–1039. [CrossRef] [PubMed] [Google Scholar]

[2] Klein L, Hinterberger M, von Rohrscheidt J, Aichinger M. Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance. Trends Immunol 2011 ; 32 : 188–193. [CrossRef] [PubMed] [Google Scholar]

[3] Surh CD, Ernst B, Sprent J. Growth of epithelial cells in the thymic medulla is under the control of mature T cells. J Exp Med 1992 ; 176 : 611–616. [CrossRef] [PubMed] [Google Scholar]

[4] Hikosaka Y, Nitta T, Ohigashi I, et al. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 2008 ; 29 : 438–450. [CrossRef] [PubMed] [Google Scholar]

[5] Irla M, Hugues S, Gill J, et al. Autoantigen-specific interactions with CD4⁺ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity 2008 ; 29 : 451–463. [CrossRef] [PubMed] [Google Scholar]

[6] Irla M, Hollander G, Reith W. Control of central self-tolerance induction by autoreactive CD4⁺ thymocytes. Trends Immunol 2010 ; 31 : 71–79. [CrossRef] [PubMed] [Google Scholar]

[7] Boehm T, Scheu S, Pfeffer K, Bleul CC. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J Exp Med 2003 ; 198 : 757–769. [CrossRef] [PubMed] [Google Scholar]

[8] Akiyama T, Shimo Y, Yanai H, et al. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity 2008 ; 29 : 423–437. [CrossRef] [PubMed] [Google Scholar]

[9] Rossi SW, Kim MY, Leibbrandt A, et al. RANK signals from CD4⁺3⁻ inducer cells regulate development of aire-expressing epithelial cells in the thymic medulla. J Exp Med 2007 ; 204 : 1267–1272. [CrossRef] [PubMed] [Google Scholar]