Sonic Hedgehog, un morphogène en quête de fonction dans le cerveau adulte

Martial Ruat; Élodie Angot; Élisabeth Traiffort

doi:doi:10.1051/medsci/20112711014

Accès gratuit

Numéro		Med Sci (Paris) Volume 27, Numéro 11, Novembre 2011


Page(s)		979 - 985
Section		M/S Revues
DOI		https://doi.org/10.1051/medsci/20112711014
Publié en ligne		30 novembre 2011

Dessaud E, McMahon AP, Briscoe J. Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 2008 ; 135 : 2489–2503. [CrossRef] [PubMed]
Traiffort E, Angot E, Ruat M. Sonic Hedgehog signaling in the mammalian brain. J Neurochem 2010 ; 113 : 576–590. [CrossRef] [PubMed]
Goetz SC, Anderson KV. The primary cilium: a signaling centre during vertebrate development. Nat Rev Genet 2010 ; 11 : 331–344. [CrossRef] [PubMed]
Simpson F, Kerr MC, Wicking C. Trafficking, development and hedgehog. Mech Dev 2009 ; 126 : 279–288. [CrossRef] [PubMed]
Fabre P, Morin S, Charron F. Sonic hedgehog et Boc. Une histoire de guidage axonal très attirante. Med Sci (Paris) 2008 ; 24 : 129–131. [CrossRef] [EDP Sciences]
Jenkins D. Hedgehog signalling: Emerging evidence for non-canonical pathways. Cell Signal 2009 ; 21 : 1023–1034. [CrossRef] [PubMed]
Borjigin J, Deng J, Wang MM, et al. Circadian rhythm of patched1 transcription in the pineal regulated by adrenergic stimulation and cAMP. J Biol Chem 1999 ; 274 : 35012–35015. [CrossRef] [PubMed]
Machold R, Hayashi S, Rutlin M, et al. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 2003 ; 39 : 937–950. [CrossRef] [PubMed]
Garcia AD, Petrova R, Eng L, Joyner AL. Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain. J Neurosci 2010 ; 30 : 13597–13608. [CrossRef] [PubMed]
Zhao C, Deng W, Gage FH. Mechanisms and functional implications of adult neurogenesis. Cell 2008 ; 132 : 645–660. [CrossRef] [PubMed]
Charytoniuk D, Traiffort E, Hantraye P, et al. Intrastriatal sonic hedgehog injection increases Patched transcript levels in the adult rat subventricular zone. Eur J Neurosci 2002 ; 16 : 2351–2357. [CrossRef] [PubMed]
Ahn S, Joyner AL. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature 2005 ; 437 : 894–897. [CrossRef] [PubMed]
Angot E, Loulier K, Nguyen-Ba-Charvet KT, et al. Chemoattractive activity of sonic hedgehog in the adult subventricular zone modulates the number of neural precursors reaching the olfactory bulb. Stem Cells 2008 ; 26 : 2311–2320. [CrossRef] [PubMed]
Palma V, Lim DA, Dahmane N, et al. Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development 2005 ; 132 : 335–344. [CrossRef] [PubMed]
Lai K, Kaspar BK, Gage FH, Schaffer DV. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci 2003 ; 6 : 21–27. [CrossRef] [PubMed]
Spassky N, Aguilar A. Cil primaire et développement cérébral. Med Sci (Paris) 2008 ; 24 : 790–791. [CrossRef] [EDP Sciences] [PubMed]
Fuccillo M, Joyner AL, Fishell G. Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development. Nat Rev Neurosci 2006 ; 7 : 772–783. [CrossRef] [PubMed]
Loulier K, Ruat M, Traiffort E. Increase of proliferating oligodendroglial progenitors in the adult mouse brain upon Sonic hedgehog delivery in the lateral ventricle. J Neurochem 2006 ; 98 : 530–542. [CrossRef] [PubMed]
Amankulor NM, Hambardzumyan D, Pyonteck SM, et al. Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation. J Neurosci 2009 ; 29 : 10299–10308. [CrossRef] [PubMed]
Bezard E, Baufreton J, Owens G, et al. Sonic hedgehog is a neuromodulator in the adult subthalamic nucleus. Faseb J 2003 ; 17 : 2337–2338. [PubMed]
Pascual O, Traiffort E, Baker DP, et al. Sonic hedgehog signalling in neurons of adult ventrolateral nucleus tractus solitarius. Eur J Neurosci 2005 ; 22 : 389–396. [CrossRef] [PubMed]
Gulino A, Arcella A, Giangaspero F. Pathological and molecular heterogeneity of medulloblastoma. Curr Opin Oncology 2008 ; 20 : 668–675. [CrossRef]
Low JA, de Sauvage FJ. Clinical experience with hedgehog pathway inhibitors. J Clin Oncol 2010 ; 28 : 5321–5326. [CrossRef] [PubMed]
Bar EE, Chaudhry A, Lin A, et al. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 2007 ; 25 : 2524–2533. [CrossRef] [PubMed]
Wu CL, Chen SD, Yin JH, et al. Erythropoietin and sonic hedgehog mediate the neuroprotective effects of brain-derived neurotrophic factor against mitochondrial inhibition. Neurobiol Dis 2010 ; 40 : 146–154. [CrossRef] [PubMed]
Banerjee SB, Rajendran R, Dias BG, et al. Recruitment of the Sonic hedgehog signalling cascade in electroconvulsive seizure-mediated regulation of adult rat hippocampal neurogenesis. Eur J Neurosci 2005 ; 22 : 1570–1580. [CrossRef] [PubMed]
Charron F, Tessier-Lavigne M. Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance. Development 2005 ; 132 : 2251–2262. [CrossRef] [PubMed]
Heine VM, Rowitch DH. Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism. J Clin Invest 2009 ; 119 : 267–277. [PubMed]
Harsan LA, Steibel J, Zaremba A, et al. Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging. J Neurosci 2008 ; 28 : 14189–14201. [CrossRef] [PubMed]
Mastronardi FG, Min W, Wang H, et al. Attenuation of experimental autoimmune encephalomyelitis and nonimmune demyelination by IFN-beta plus vitamin B12: treatment to modify notch-1/sonic hedgehog balance. J Immunol 2004 ; 172 : 6418–6426. [PubMed]

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[1] Dessaud E, McMahon AP, Briscoe J. Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 2008 ; 135 : 2489–2503. [CrossRef] [PubMed]

[2] Traiffort E, Angot E, Ruat M. Sonic Hedgehog signaling in the mammalian brain. J Neurochem 2010 ; 113 : 576–590. [CrossRef] [PubMed]

[3] Goetz SC, Anderson KV. The primary cilium: a signaling centre during vertebrate development. Nat Rev Genet 2010 ; 11 : 331–344. [CrossRef] [PubMed]

[4] Simpson F, Kerr MC, Wicking C. Trafficking, development and hedgehog. Mech Dev 2009 ; 126 : 279–288. [CrossRef] [PubMed]

[5] Fabre P, Morin S, Charron F. Sonic hedgehog et Boc. Une histoire de guidage axonal très attirante. Med Sci (Paris) 2008 ; 24 : 129–131. [CrossRef] [EDP Sciences]

[6] Jenkins D. Hedgehog signalling: Emerging evidence for non-canonical pathways. Cell Signal 2009 ; 21 : 1023–1034. [CrossRef] [PubMed]

[7] Borjigin J, Deng J, Wang MM, et al. Circadian rhythm of patched1 transcription in the pineal regulated by adrenergic stimulation and cAMP. J Biol Chem 1999 ; 274 : 35012–35015. [CrossRef] [PubMed]

[8] Machold R, Hayashi S, Rutlin M, et al. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 2003 ; 39 : 937–950. [CrossRef] [PubMed]

[9] Garcia AD, Petrova R, Eng L, Joyner AL. Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain. J Neurosci 2010 ; 30 : 13597–13608. [CrossRef] [PubMed]

[10] Zhao C, Deng W, Gage FH. Mechanisms and functional implications of adult neurogenesis. Cell 2008 ; 132 : 645–660. [CrossRef] [PubMed]

[11] Charytoniuk D, Traiffort E, Hantraye P, et al. Intrastriatal sonic hedgehog injection increases Patched transcript levels in the adult rat subventricular zone. Eur J Neurosci 2002 ; 16 : 2351–2357. [CrossRef] [PubMed]

[12] Ahn S, Joyner AL. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature 2005 ; 437 : 894–897. [CrossRef] [PubMed]

[13] Angot E, Loulier K, Nguyen-Ba-Charvet KT, et al. Chemoattractive activity of sonic hedgehog in the adult subventricular zone modulates the number of neural precursors reaching the olfactory bulb. Stem Cells 2008 ; 26 : 2311–2320. [CrossRef] [PubMed]

[14] Palma V, Lim DA, Dahmane N, et al. Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development 2005 ; 132 : 335–344. [CrossRef] [PubMed]

[15] Lai K, Kaspar BK, Gage FH, Schaffer DV. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci 2003 ; 6 : 21–27. [CrossRef] [PubMed]

[16] Spassky N, Aguilar A. Cil primaire et développement cérébral. Med Sci (Paris) 2008 ; 24 : 790–791. [CrossRef] [EDP Sciences] [PubMed]

[17] Fuccillo M, Joyner AL, Fishell G. Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development. Nat Rev Neurosci 2006 ; 7 : 772–783. [CrossRef] [PubMed]

[18] Loulier K, Ruat M, Traiffort E. Increase of proliferating oligodendroglial progenitors in the adult mouse brain upon Sonic hedgehog delivery in the lateral ventricle. J Neurochem 2006 ; 98 : 530–542. [CrossRef] [PubMed]

[19] Amankulor NM, Hambardzumyan D, Pyonteck SM, et al. Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation. J Neurosci 2009 ; 29 : 10299–10308. [CrossRef] [PubMed]

[20] Bezard E, Baufreton J, Owens G, et al. Sonic hedgehog is a neuromodulator in the adult subthalamic nucleus. Faseb J 2003 ; 17 : 2337–2338. [PubMed]

[21] Pascual O, Traiffort E, Baker DP, et al. Sonic hedgehog signalling in neurons of adult ventrolateral nucleus tractus solitarius. Eur J Neurosci 2005 ; 22 : 389–396. [CrossRef] [PubMed]

[22] Gulino A, Arcella A, Giangaspero F. Pathological and molecular heterogeneity of medulloblastoma. Curr Opin Oncology 2008 ; 20 : 668–675. [CrossRef]

[23] Low JA, de Sauvage FJ. Clinical experience with hedgehog pathway inhibitors. J Clin Oncol 2010 ; 28 : 5321–5326. [CrossRef] [PubMed]

[24] Bar EE, Chaudhry A, Lin A, et al. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 2007 ; 25 : 2524–2533. [CrossRef] [PubMed]

[25] Wu CL, Chen SD, Yin JH, et al. Erythropoietin and sonic hedgehog mediate the neuroprotective effects of brain-derived neurotrophic factor against mitochondrial inhibition. Neurobiol Dis 2010 ; 40 : 146–154. [CrossRef] [PubMed]

[26] Banerjee SB, Rajendran R, Dias BG, et al. Recruitment of the Sonic hedgehog signalling cascade in electroconvulsive seizure-mediated regulation of adult rat hippocampal neurogenesis. Eur J Neurosci 2005 ; 22 : 1570–1580. [CrossRef] [PubMed]

[27] Charron F, Tessier-Lavigne M. Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance. Development 2005 ; 132 : 2251–2262. [CrossRef] [PubMed]

[28] Heine VM, Rowitch DH. Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism. J Clin Invest 2009 ; 119 : 267–277. [PubMed]

[29] Harsan LA, Steibel J, Zaremba A, et al. Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging. J Neurosci 2008 ; 28 : 14189–14201. [CrossRef] [PubMed]

[30] Mastronardi FG, Min W, Wang H, et al. Attenuation of experimental autoimmune encephalomyelitis and nonimmune demyelination by IFN-beta plus vitamin B12: treatment to modify notch-1/sonic hedgehog balance. J Immunol 2004 ; 172 : 6418–6426. [PubMed]