Nouvelle stratégie pour cibler la réplication du virus de la grippe

Alexandre Dias; Denis Bouvier; Stephen Cusack; Rob W.H. Ruigrok; Thibaut Crépin

doi:10.1051/medsci/2009254352

Accueil

Tous les numéros

Volume 25 / Numéro 4 (Avril 2009)

Med Sci (Paris), 25 4 (2009) 352-354

Références

Accès gratuit

Numéro		Med Sci (Paris) Volume 25, Numéro 4, Avril 2009


Page(s)		352 - 354
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/2009254352
Publié en ligne		15 avril 2009

Rao P, Yuan W, Krug RM. Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis. EMBO J 2003; 22 : 1188–9. [Google Scholar]
Guilligay D, Tarendeau F, Resa-Infante P, et al. The structural basis for cap binding by influenza virus polymerase subunit PB2. Nat Struct Mol Biol 2008; 15 : 500–6. [Google Scholar]
Shi L, Summers DF, Peng Q, Galarz JM. Influenza A virus RNA polymerase subunit PB2 is the endonuclease which cleaves host cell mRNA and functions only as the trimeric enzyme. Virology 1995; 208 : 38–47. [Google Scholar]
Li ML, Rao P, Krug RM. The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits. EMBO J 2001; 20 : 2078–86. [Google Scholar]
Dias A, Bouvier D, Crépin T, et al. The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit. Nature 2009, 4 février (online). [Google Scholar]
Horton NC, Perona JJ. DNA cleavage by EcoRV endonuclease: two metal ions in three metal ion binding sites. Biochemistry 2004; 43 : 6841–57. [Google Scholar]
Hara K, Schmidt FI, Crow M, Brownlee GG. Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding. J Virol 2006; 80 : 7789–98. [Google Scholar]
Doan L, Handa B, Roberts NA, Klumpp K. Metal ion catalysis of RNA cleavage by the influenza virus endonuclease. Biochemistry 1996; 38 : 5612–9. [Google Scholar]
Tomassini J, Selnick H, Davies ME, et al. Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds. Antimicrob Agents Chemother 1994; 38 : 2827–37. [Google Scholar]

Les statistiques affichées correspondent au cumul d'une part des vues des résumés de l'article et d'autre part des vues et téléchargements de l'article plein-texte (PDF, Full-HTML, ePub... selon les formats disponibles) sur la platefome Vision4Press.

Les statistiques sont disponibles avec un délai de 48 à 96 heures et sont mises à jour quotidiennement en semaine.

Le chargement des statistiques peut être long.

[1] Rao P, Yuan W, Krug RM. Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis. EMBO J 2003; 22 : 1188–9. [Google Scholar]

[2] Guilligay D, Tarendeau F, Resa-Infante P, et al. The structural basis for cap binding by influenza virus polymerase subunit PB2. Nat Struct Mol Biol 2008; 15 : 500–6. [Google Scholar]

[3] Shi L, Summers DF, Peng Q, Galarz JM. Influenza A virus RNA polymerase subunit PB2 is the endonuclease which cleaves host cell mRNA and functions only as the trimeric enzyme. Virology 1995; 208 : 38–47. [Google Scholar]

[4] Li ML, Rao P, Krug RM. The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits. EMBO J 2001; 20 : 2078–86. [Google Scholar]

[5] Dias A, Bouvier D, Crépin T, et al. The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit. Nature 2009, 4 février (online). [Google Scholar]

[6] Horton NC, Perona JJ. DNA cleavage by EcoRV endonuclease: two metal ions in three metal ion binding sites. Biochemistry 2004; 43 : 6841–57. [Google Scholar]

[7] Hara K, Schmidt FI, Crow M, Brownlee GG. Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding. J Virol 2006; 80 : 7789–98. [Google Scholar]

[8] Doan L, Handa B, Roberts NA, Klumpp K. Metal ion catalysis of RNA cleavage by the influenza virus endonuclease. Biochemistry 1996; 38 : 5612–9. [Google Scholar]

[9] Tomassini J, Selnick H, Davies ME, et al. Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds. Antimicrob Agents Chemother 1994; 38 : 2827–37. [Google Scholar]