Métabonomique et cartographie génétique

Dominique Gauguier; Marc-Emmanuel Dumas

doi:10.1051/medsci/200723121091

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Volume 23 / Numéro 12 (Décembre 2007)

Med Sci (Paris), 23 12 (2007) 1091-1094

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Numéro		Med Sci (Paris) Volume 23, Numéro 12, Décembre 2007


Page(s)		1091 - 1094
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/200723121091
Publié en ligne		15 décembre 2007

Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447 : 661–78. [Google Scholar]
Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316 : 889–94. [Google Scholar]
Schadt EE, Monks SA, Drake TA, et al. Genetics of gene expression surveyed in maize, mouse and man. Nature 2003; 422 : 297–302. [Google Scholar]
Nicholson JK, Connelly J, Lindon JC, Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov 2002; 1 : 153–61. [Google Scholar]
Clayton TA, Lindon JC, Cloarec O, et al. Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 2006; 440 : 1073–7. [Google Scholar]
Brindle JT, Antti H, Holmes E, et al. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat Med 2002; 8 : 1439–44. [Google Scholar]
Dumas ME, Wilder SP, Bihoreau MT, et al. Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models. Nat Genet 2007; 39 : 666–72. [Google Scholar]
Nicholson JK, Holmes E, Wilson ID. Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol 2005; 3 : 431–8. [Google Scholar]
Turnbaugh PJ, Ley RE, Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006; 444 : 1027–31. [Google Scholar]
Dumas ME, Barton RH, Toye A, et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci USA 2006; 103 : 12511–6. [Google Scholar]
Gauguier D, Froguel P, Parent V, et al. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 1996; 12 : 38–43. [Google Scholar]
Argoud K, Wilder SP, McAteer MA, et al. Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto-Kakizaki rats. Diabetologia 2006; 49 : 2679–88. [Google Scholar]
Rogner UC, Avner P. Congenic mice: cutting tools for complex immune disorders. Nat Rev Immunol 2003; 3 : 243–52. [Google Scholar]
Gilgamesh S, Kaprank JC. La compassion et le chacun-pour-soi : deux volets d’un même QTL. Med Sci (Paris) : 2007; 23 : 445–6. [Google Scholar]

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[1] Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447 : 661–78. [Google Scholar]

[2] Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316 : 889–94. [Google Scholar]

[3] Schadt EE, Monks SA, Drake TA, et al. Genetics of gene expression surveyed in maize, mouse and man. Nature 2003; 422 : 297–302. [Google Scholar]

[4] Nicholson JK, Connelly J, Lindon JC, Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov 2002; 1 : 153–61. [Google Scholar]

[5] Clayton TA, Lindon JC, Cloarec O, et al. Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 2006; 440 : 1073–7. [Google Scholar]

[6] Brindle JT, Antti H, Holmes E, et al. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat Med 2002; 8 : 1439–44. [Google Scholar]

[7] Dumas ME, Wilder SP, Bihoreau MT, et al. Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models. Nat Genet 2007; 39 : 666–72. [Google Scholar]

[8] Nicholson JK, Holmes E, Wilson ID. Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol 2005; 3 : 431–8. [Google Scholar]

[9] Turnbaugh PJ, Ley RE, Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006; 444 : 1027–31. [Google Scholar]

[10] Dumas ME, Barton RH, Toye A, et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci USA 2006; 103 : 12511–6. [Google Scholar]

[11] Gauguier D, Froguel P, Parent V, et al. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 1996; 12 : 38–43. [Google Scholar]

[12] Argoud K, Wilder SP, McAteer MA, et al. Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto-Kakizaki rats. Diabetologia 2006; 49 : 2679–88. [Google Scholar]

[13] Rogner UC, Avner P. Congenic mice: cutting tools for complex immune disorders. Nat Rev Immunol 2003; 3 : 243–52. [Google Scholar]

[14] Gilgamesh S, Kaprank JC. La compassion et le chacun-pour-soi : deux volets d’un même QTL. Med Sci (Paris) : 2007; 23 : 445–6. [Google Scholar]