L’autophagie et le dernier soupir de la cellule

Sophie Pattingre; Patrice Codogno

doi:10.1051/medsci/20072389696

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Volume 23 / Numéro 8-9 (Août-Septembre 2007)

Med Sci (Paris), 23 8-9 (2007) 696-698

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Numéro		Med Sci (Paris) Volume 23, Numéro 8-9, Août-Septembre 2007


Page(s)		696 - 698
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/20072389696
Publié en ligne		15 août 2007

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Espert L, Denizot M, Grimaldi M, et al. Autophagie et destruction des lymphocytes T CD4 par le VIH-1. Med Sci (Paris) 2006; 22 : 677–8. [Google Scholar]
Pattingre S, Tassa A, Qu X, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122 : 927–39. [Google Scholar]
Rubinsztein DC, Gestwicki JE, Murphy LO, Klionsky DJ. Potential therapeutic applications of autophagy. Nat Rev Drug Discov 2007; 6 : 304–12. [Google Scholar]
Qu X, Zou Z, Sun Q, et al. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell. 2007; 128 : 931–46. [Google Scholar]
Grimsley C, Ravichandran KS. Cues for apoptotic cell engulfment: eat-me, don’t eat-me and come-get-me signals. Trends Cell Biol 2003; 13 : 648–56. [Google Scholar]
Qu X, Yu J, Bhagat G, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112 : 1809–20. [Google Scholar]
Yue Z, Jin S, Yang C, et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 25 : 15077–82. [Google Scholar]

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[1] De Duve C, Wattiaux R. Functions of lysosomes. Annu Rev Physiol 1966; 28 : 435. [Google Scholar]

[2] Codogno P. Les gènes atg et la macroautophagie. Med Sci (Paris) 2004; 20 : 734–6. [Google Scholar]

[3] Metzstein MM, Stanfield GM, Horvitz HR. Genetics of programmed cell death in C. elegans: past, present and future. Trends Genet 1998; 14 : 410–6. [Google Scholar]

[4] Hara T, Nakamura K, Matsui M, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441 : 885–9. [Google Scholar]

[5] Komatsu M, Waguri S, Chiba T, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 44 : 880–4. [Google Scholar]

[6] Kuma A, Hatano M, Matsui M, et al. The role of autophagy during the early neonatal starvation period. Nature 2004; 432 : 1032–6. [Google Scholar]

[7] Boya P, Gonzalez-Polo RA, Casares N, et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005; 25 : 1025–40. [Google Scholar]

[8] Deretic V. Autophagy as an immune defense mechanism. Curr Opin Immunol 2006; 18 : 375–82. [Google Scholar]

[9] Gozuacik D, Kimchi A. Autophagy and cell death. Curr Top Dev Biol 2007; 78 : 217–45. [Google Scholar]

[10] Espert L, Denizot M, Grimaldi M, et al. Autophagie et destruction des lymphocytes T CD4 par le VIH-1. Med Sci (Paris) 2006; 22 : 677–8. [Google Scholar]

[11] Pattingre S, Tassa A, Qu X, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122 : 927–39. [Google Scholar]

[12] Rubinsztein DC, Gestwicki JE, Murphy LO, Klionsky DJ. Potential therapeutic applications of autophagy. Nat Rev Drug Discov 2007; 6 : 304–12. [Google Scholar]

[13] Qu X, Zou Z, Sun Q, et al. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell. 2007; 128 : 931–46. [Google Scholar]

[14] Grimsley C, Ravichandran KS. Cues for apoptotic cell engulfment: eat-me, don’t eat-me and come-get-me signals. Trends Cell Biol 2003; 13 : 648–56. [Google Scholar]

[15] Qu X, Yu J, Bhagat G, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112 : 1809–20. [Google Scholar]

[16] Yue Z, Jin S, Yang C, et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 25 : 15077–82. [Google Scholar]