La voie Notch au centre du mécanisme de leucémogenèse dans un modèle murin de leucémies T

Philippe Kastner; Susan Chan

doi:10.1051/medsci/20062289708

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Volume 22 / Numéro 8-9 (Août–Septembre 2006)

Med Sci (Paris), 22 8-9 (2006) 708-710

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Numéro		Med Sci (Paris) Volume 22, Numéro 8-9, Août–Septembre 2006


Page(s)		708 - 710
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/20062289708
Publié en ligne		15 août 2006

Weng AP, Ferrando AA, Lee W, et al. Activating mutations of Notch1 in human T cell acute lymphoblastic leukemia. Science 2004; 306 : 269–71. [Google Scholar]
Dumortier A, Jeannet R, Kirstetter P, et al. Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice. Mol Cell Biol 2006; 26 : 209–20. [Google Scholar]
Kirstetter P, Thomas M, Dierich A, et al. Ikaros is critical for B cell differentiation and function. Eur J Immunol 2002; 32 : 720–3. [Google Scholar]
Koipally J, Renold A, Kim J, et al. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J 1999; 18 : 3090–100. [Google Scholar]
Lopez-Nieva P, Santos J, Fernandez-Piqueras J. Defective expression of Notch1 and Notch2 in connection to alterations of c-Myc and Ikaros in gamma-radiation-induced mouse thymic lymphomas. Carcinogenesis 2004; 25 : 1299–304. [Google Scholar]
Karlsson A, Soderkvist P, Zhuang SM. Point mutations and deletions in the znfn1a1/ikaros gene in chemically induced murine lymphomas. Cancer Res 2002; 62 : 2650–3. [Google Scholar]
Shimada Y, Nishimura M, Kakinuma S, et al. Radiation-associated loss of heterozygosity at the Znfn1a1 (Ikaros) locus on chromosome 11 in murine thymic lymphomas. Radiat Res 2000; 154 : 293–300. [Google Scholar]
Winandy S, Wu P, Georgopoulos K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 1995; 83 : 289–99. [Google Scholar]
Papathanasiou P, Perkins AC, Cobb BS, et al. Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity 2003; 19 : 131–44. [Google Scholar]
Beverly L, Capobianco AJ. Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis. Cancer Cell 2003; 3 : 551–64. [Google Scholar]

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[1] Weng AP, Ferrando AA, Lee W, et al. Activating mutations of Notch1 in human T cell acute lymphoblastic leukemia. Science 2004; 306 : 269–71. [Google Scholar]

[2] Dumortier A, Jeannet R, Kirstetter P, et al. Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice. Mol Cell Biol 2006; 26 : 209–20. [Google Scholar]

[3] Kirstetter P, Thomas M, Dierich A, et al. Ikaros is critical for B cell differentiation and function. Eur J Immunol 2002; 32 : 720–3. [Google Scholar]

[4] Koipally J, Renold A, Kim J, et al. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J 1999; 18 : 3090–100. [Google Scholar]

[5] Lopez-Nieva P, Santos J, Fernandez-Piqueras J. Defective expression of Notch1 and Notch2 in connection to alterations of c-Myc and Ikaros in gamma-radiation-induced mouse thymic lymphomas. Carcinogenesis 2004; 25 : 1299–304. [Google Scholar]

[6] Karlsson A, Soderkvist P, Zhuang SM. Point mutations and deletions in the znfn1a1/ikaros gene in chemically induced murine lymphomas. Cancer Res 2002; 62 : 2650–3. [Google Scholar]

[7] Shimada Y, Nishimura M, Kakinuma S, et al. Radiation-associated loss of heterozygosity at the Znfn1a1 (Ikaros) locus on chromosome 11 in murine thymic lymphomas. Radiat Res 2000; 154 : 293–300. [Google Scholar]

[8] Winandy S, Wu P, Georgopoulos K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 1995; 83 : 289–99. [Google Scholar]

[9] Papathanasiou P, Perkins AC, Cobb BS, et al. Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity 2003; 19 : 131–44. [Google Scholar]

[10] Beverly L, Capobianco AJ. Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis. Cancer Cell 2003; 3 : 551–64. [Google Scholar]