Cernunnos, un nouveau facteur de la réparation de l’ADN essentiel pour le système immunitaire

Patrick Revy; Jean-Pierre de Villartay

doi:10.1051/medsci/20062267569

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Volume 22 / Numéro 6-7 (Juin-Juillet 2006)

Med Sci (Paris), 22 6-7 (2006) 569-570

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Numéro		Med Sci (Paris) Volume 22, Numéro 6-7, Juin-Juillet 2006


Page(s)		569 - 570
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/20062267569
Publié en ligne		15 juin 2006

Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, et al. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 2004; 73 : 39–85. [Google Scholar]
Weterings E, Van Gent DC. The mechanism of non-homologous end-joining : a synopsis of synapsis. DNA Repair (Amst) 2004; 3 : 1425–35. [Google Scholar]
Revy P, Buck D, Le Deist F, et al. The repair of DNA damages/modifications during the maturation of the immune system : lessons from human primary immunofeficiency disorders and animal models. Adv Immunol 2005; 87 : 237–95. [Google Scholar]
Bassing CH, Alt FW. The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) 2004; 3 : 781–96. [Google Scholar]
Moshous D, Callebaut I, De Chasseval R, et al. ARTEMIS, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 2001; 105 : 177–86. [Google Scholar]
O’Driscoll M, Cerosaletti KM, Girard PM, et al. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol Cell 2001; 8 : 1175–85. [Google Scholar]
Buck D, Moshous D, De Chasseval R, et al. Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. Eur J Immunol 2006; 36 : 224–35. [Google Scholar]
Buck D, Malivert L, De Chasseval R, et al. Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell 2006; 124 : 287–99. [Google Scholar]
Ahnesorg P, Smith P, Jackson SP. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 2006; 124 : 301–13. [Google Scholar]
Callebaut I, Malivert L, Fischer A, Mornon JP, Revy P, de Villartay JP. Cernunnos interacts with the XRCC4/DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor NEJ1. J Biol Chem 2006 online (sous presse). [Google Scholar]

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[1] Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, et al. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 2004; 73 : 39–85. [Google Scholar]

[2] Weterings E, Van Gent DC. The mechanism of non-homologous end-joining : a synopsis of synapsis. DNA Repair (Amst) 2004; 3 : 1425–35. [Google Scholar]

[3] Revy P, Buck D, Le Deist F, et al. The repair of DNA damages/modifications during the maturation of the immune system : lessons from human primary immunofeficiency disorders and animal models. Adv Immunol 2005; 87 : 237–95. [Google Scholar]

[4] Bassing CH, Alt FW. The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) 2004; 3 : 781–96. [Google Scholar]

[5] Moshous D, Callebaut I, De Chasseval R, et al. ARTEMIS, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 2001; 105 : 177–86. [Google Scholar]

[6] O’Driscoll M, Cerosaletti KM, Girard PM, et al. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol Cell 2001; 8 : 1175–85. [Google Scholar]

[7] Buck D, Moshous D, De Chasseval R, et al. Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. Eur J Immunol 2006; 36 : 224–35. [Google Scholar]

[8] Buck D, Malivert L, De Chasseval R, et al. Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell 2006; 124 : 287–99. [Google Scholar]

[9] Ahnesorg P, Smith P, Jackson SP. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 2006; 124 : 301–13. [Google Scholar]

[10] Callebaut I, Malivert L, Fischer A, Mornon JP, Revy P, de Villartay JP. Cernunnos interacts with the XRCC4/DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor NEJ1. J Biol Chem 2006 online (sous presse). [Google Scholar]