Hfe : une molécule à l’interface entre immunité et métabolisme du fer ?

Pierre-Simon Rohrlich; Jean Kanellopoulos; Francois A. Lemonnier

doi:10.1051/medsci/200622124

Accès gratuit

Numéro		Med Sci (Paris) Volume 22, Numéro 1, Janvier 2006


Page(s)		24 - 26
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/200622124
Publié en ligne		15 janvier 2006

Lebron JA, Bennett MJ, Vaughn DE, et al. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 1998; 93 : 111–23. [Google Scholar]
Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996; 13 : 399–408. [Google Scholar]
Bennett MJ, Lebron JA, Bjorkman PJ. Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor. Nature 2000; 403 : 46–53. [Google Scholar]
Bahram S, Gilfillan S, Kuhn LC, et al. Experimental hemochromatosis due to MHC class I HFE deficiency : immune status and iron metabolism. Proc Natl Acad Sci USA 1999; 96 : 13312–7. [Google Scholar]
Rohrlich PS, Fazilleau N, Ginhoux F, et al. Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function. Proc Natl Acad Sci USA 2005; 102 : 12855–60. [Google Scholar]
Cardoso EM, Hagen K, de Sousa M, Hultcrantz R. Hepatic damage in C282Y homozygotes relates to low numbers of CD8⁺ cells in the liver lobuli. Eur J Clin Invest 2001; 31 : 45–53. [Google Scholar]
Santos MM, de Sousa M, Rademakers LH, et al. Iron overload and heart fibrosis in mice deficient for both beta2-microglobulin and Rag1. Am J Pathol 2000; 157 : 1883–92. [Google Scholar]
Meyer PN, Gerhard GS, Yoshida Y, et al. Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels : elements of a common gut pathway ? Blood Cells Mol Dis 2002; 29 : 274–85. [Google Scholar]
Yewdell JW, Hickman-Miller HD. Back to the fold : T cell recognition of HFE, a MHC class Ib molecule that regulates iron metabolism. Proc Natl Acad Sci USA 2005; 102 : 12649–50. [Google Scholar]
Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003; 361 : 669–73. [Google Scholar]
Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004; 113 : 1271–6. [Google Scholar]

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[1] Lebron JA, Bennett MJ, Vaughn DE, et al. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 1998; 93 : 111–23. [Google Scholar]

[2] Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996; 13 : 399–408. [Google Scholar]

[3] Bennett MJ, Lebron JA, Bjorkman PJ. Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor. Nature 2000; 403 : 46–53. [Google Scholar]

[4] Bahram S, Gilfillan S, Kuhn LC, et al. Experimental hemochromatosis due to MHC class I HFE deficiency : immune status and iron metabolism. Proc Natl Acad Sci USA 1999; 96 : 13312–7. [Google Scholar]

[5] Rohrlich PS, Fazilleau N, Ginhoux F, et al. Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function. Proc Natl Acad Sci USA 2005; 102 : 12855–60. [Google Scholar]

[6] Cardoso EM, Hagen K, de Sousa M, Hultcrantz R. Hepatic damage in C282Y homozygotes relates to low numbers of CD8⁺ cells in the liver lobuli. Eur J Clin Invest 2001; 31 : 45–53. [Google Scholar]

[7] Santos MM, de Sousa M, Rademakers LH, et al. Iron overload and heart fibrosis in mice deficient for both beta2-microglobulin and Rag1. Am J Pathol 2000; 157 : 1883–92. [Google Scholar]

[8] Meyer PN, Gerhard GS, Yoshida Y, et al. Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels : elements of a common gut pathway ? Blood Cells Mol Dis 2002; 29 : 274–85. [Google Scholar]

[9] Yewdell JW, Hickman-Miller HD. Back to the fold : T cell recognition of HFE, a MHC class Ib molecule that regulates iron metabolism. Proc Natl Acad Sci USA 2005; 102 : 12649–50. [Google Scholar]

[10] Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003; 361 : 669–73. [Google Scholar]

[11] Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004; 113 : 1271–6. [Google Scholar]