Les inhibiteurs de la protéase virale du VIH affectent le facteur de transcription SREBP-1

Martine Caron; Jean-Philippe Bastard; Corinne Vigouroux; Véronique Jan; Mustapha Maachi; Martine Auclair; Jacqueline Capeau

doi:10.1051/medsci/20021867657

Accès gratuit

Numéro		Med Sci (Paris) Volume 18, Numéro 6-7, Juin–Juillet 2002


Page(s)		657 - 659
Section		Le Magazine : Nouvelles
DOI		https://doi.org/10.1051/medsci/20021867657
Publié en ligne		15 juin 2002

Saves M, Mercié P, Chène G. Syndromes lipodystrophiques et traitements antirétroviraux chez les patients infectés par le VIH-1. Med Sci 2001; 17 : 886–92 [Google Scholar]
Nolan D, John M, Mallal S. Antiretroviral therapy and the lipodystrophy syndrome, part 2: concepts in aetiopathogenesis. Antiviral Ther 2001; 6 : 145–60. [Google Scholar]
Murata H, Hruz PW, Mueckler M. The mechanism of insulin resistance caused by HIV protease inhibitor therapy. J Biol Chem 2000; 275 : 20251–4. [Google Scholar]
Dowell P, Flexner C, Kwiterich PO, Lane MD. Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors. J Biol Chem 2000; 275 : 41325–32. [Google Scholar]
Caron M, Auclair M, Vigouroux C, Glorian M, ForestC, CapeauJ. The HIV protease inhibitor indinavir impairs sterol regulatory element binding protein-1 intranuclear localization, inhibits preadipocyte differentiation and induces insulin resistance. Diabetes 2001; 50 : 1378–88. [Google Scholar]
Caron M, Auclair M, Kornprobst M, Capeau J. Step by step evaluation of the impact of different protease inhibition on adipogenesis : pathophysiological insights and relevance to the clinic. CROI 2002; E90T. [Google Scholar]
Vigouroux C, Auclair M, Dubosclard E, et al. Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q/W mutations in the lamin A/C gene. J Cell Sci 2001; 114 : 4459–68. [Google Scholar]
Shikuma CM, Hu N, Milne C, et al. Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy. AIDS 2001; 15 : 1801–9. [Google Scholar]
Domingo P, Matias-Guiu X, Pujol RM, et al. Subcutaneaous adipocyte apoptosis in HIV-1 protease inhibitor associated lipodystrophy. AIDS 1999; 13 : 2261–7. [Google Scholar]
Bastard JP, Caron M, Vidal H, et al. Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance. Lancet 2002; 359 : 1026–31. [Google Scholar]

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[1] Saves M, Mercié P, Chène G. Syndromes lipodystrophiques et traitements antirétroviraux chez les patients infectés par le VIH-1. Med Sci 2001; 17 : 886–92 [Google Scholar]

[2] Nolan D, John M, Mallal S. Antiretroviral therapy and the lipodystrophy syndrome, part 2: concepts in aetiopathogenesis. Antiviral Ther 2001; 6 : 145–60. [Google Scholar]

[3] Murata H, Hruz PW, Mueckler M. The mechanism of insulin resistance caused by HIV protease inhibitor therapy. J Biol Chem 2000; 275 : 20251–4. [Google Scholar]

[4] Dowell P, Flexner C, Kwiterich PO, Lane MD. Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors. J Biol Chem 2000; 275 : 41325–32. [Google Scholar]

[5] Caron M, Auclair M, Vigouroux C, Glorian M, ForestC, CapeauJ. The HIV protease inhibitor indinavir impairs sterol regulatory element binding protein-1 intranuclear localization, inhibits preadipocyte differentiation and induces insulin resistance. Diabetes 2001; 50 : 1378–88. [Google Scholar]

[6] Caron M, Auclair M, Kornprobst M, Capeau J. Step by step evaluation of the impact of different protease inhibition on adipogenesis : pathophysiological insights and relevance to the clinic. CROI 2002; E90T. [Google Scholar]

[7] Vigouroux C, Auclair M, Dubosclard E, et al. Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q/W mutations in the lamin A/C gene. J Cell Sci 2001; 114 : 4459–68. [Google Scholar]

[8] Shikuma CM, Hu N, Milne C, et al. Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy. AIDS 2001; 15 : 1801–9. [Google Scholar]

[9] Domingo P, Matias-Guiu X, Pujol RM, et al. Subcutaneaous adipocyte apoptosis in HIV-1 protease inhibitor associated lipodystrophy. AIDS 1999; 13 : 2261–7. [Google Scholar]

[10] Bastard JP, Caron M, Vidal H, et al. Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance. Lancet 2002; 359 : 1026–31. [Google Scholar]