La kinase FRAP/mTOR : une nouvelle cible dans le traitement des cancers dépendants de la voie PI3-kinase/PTEN

Catherine Greenland; Georges Delsol; Bernard Payrastre

doi:10.1051/medsci/2002182137

Accès gratuit

Numéro		Med Sci (Paris) Volume 18, Numéro 2, Février 2002


Page(s)		137 - 139
Section		Le Magazine : Nouvelles
DOI		https://doi.org/10.1051/medsci/2002182137
Publié en ligne		15 février 2002

Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTENdeficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci USA 2001; 98 : 10314–9. [Google Scholar]
Podsypanina K, Lee RT, Politis C, et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten^+/−mice. Proc Natl Acad Sci USA 2001; 98 : 10320–5. [Google Scholar]
Mills GB, Lu Y, Kohn EC. Linking molecular therapeutics to molecular diagnostics : inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc Natl Acad Sci USA 2001; 98 : 10031–3. [Google Scholar]
Brooksbank C. Therapeutic targets : withdrawal symptoms. Nat Rev Cancer 2001; 1 : 6–11. [Google Scholar]
Vanhaesebroeck B, Leevers SJ, Khatereh A, et al. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 2001; 70 : 535–602. [Google Scholar]
Stein RC, Waterfield MD. PI 3-kinase inhibition : a target for drug development ? Mol Med Today 2000; 6 : 347–57. [Google Scholar]
Payrastre B, Missy K, Giuriato S, et al. Phosphoinositides : key players in cell signalling, in time and space. Cell Signal 2001; 13 : 377–87. [Google Scholar]
Di Cristofano A, Pandolfi PP. The multiples roles of PTEN in tumor suppression. Cell 2000;100 : 387–90. [Google Scholar]
Ali IU, Schriml LM, Dean M. Mutational spectra of PTEN/MMAC gene : a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst 1999; 91 : 1922–32. [Google Scholar]
Maehama T, Taylor GS, Dixon JE. PTEN and myotubularin :novel phosphoinositide phosphatases. Annu Rev Biochem 2001; 70 : 247–79 [Google Scholar]

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[1] Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTENdeficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci USA 2001; 98 : 10314–9. [Google Scholar]

[2] Podsypanina K, Lee RT, Politis C, et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten^+/−mice. Proc Natl Acad Sci USA 2001; 98 : 10320–5. [Google Scholar]

[3] Mills GB, Lu Y, Kohn EC. Linking molecular therapeutics to molecular diagnostics : inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc Natl Acad Sci USA 2001; 98 : 10031–3. [Google Scholar]

[4] Brooksbank C. Therapeutic targets : withdrawal symptoms. Nat Rev Cancer 2001; 1 : 6–11. [Google Scholar]

[5] Vanhaesebroeck B, Leevers SJ, Khatereh A, et al. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 2001; 70 : 535–602. [Google Scholar]

[6] Stein RC, Waterfield MD. PI 3-kinase inhibition : a target for drug development ? Mol Med Today 2000; 6 : 347–57. [Google Scholar]

[7] Payrastre B, Missy K, Giuriato S, et al. Phosphoinositides : key players in cell signalling, in time and space. Cell Signal 2001; 13 : 377–87. [Google Scholar]

[8] Di Cristofano A, Pandolfi PP. The multiples roles of PTEN in tumor suppression. Cell 2000;100 : 387–90. [Google Scholar]

[9] Ali IU, Schriml LM, Dean M. Mutational spectra of PTEN/MMAC gene : a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst 1999; 91 : 1922–32. [Google Scholar]

[10] Maehama T, Taylor GS, Dixon JE. PTEN and myotubularin :novel phosphoinositide phosphatases. Annu Rev Biochem 2001; 70 : 247–79 [Google Scholar]