Figure 1.
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Représentation schématique des principales molécules possédant un potentiel thérapeutique et ciblant les voies de signalisation calcique dans les cellules de LAM (voir Tableau 1). TRPM2 : transient receptor potential cation channel, subfamily M, member 2 ; LAM : leucémie aiguë myéloïde ; ROS : espèces réactives de l’oxygène ; AURKA : Aurora kinase A ; PLSCR1 : phospholipid scramblase 1 ; IP3R1 : inositol 1,4,5-trisphosphate receptor type 1 ; P2X7R : P2X purinoceptor 7 ; SOC : store-operated channels ; STAT5 : signal transducer and activator of transcription 5 ; CREB : C-AMP response element-binding protein ; ATF4 : activating transcription factor 4 ; VGCC : voltage-gated calcium channels.
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