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Tableau I.
Système G1e des variants d’IgG1.
| Numérotation G1e | Dénominations communes internationales | Année de première mise sur le marché | Nature de l’ingénierie de la chaîne lourde (Numérotation Eu) |
|---|---|---|---|
| G1e0 | nombreuses | Dès 1997 | Aucune ingénierie |
| G1e1 | abatacept, bélatacept | 2005 | Substitutions C220S, C226S, C229S, P238S |
| G1e2 | romiplostim | 2008 | Production dans E. coli (aglycosylation) |
| G1e3 | aflibercept, efmoroctocog α, eftrenonacog α | 2011 | Délétion des cinq premiers acides aminés de la région charnière |
| G1e4 | mogamulizumab | 2012 | Afucosylation |
| G1e5 | obinutuzumab | 2013 | Addition d’une GlcNAc bissectrice |
| G1e6 | bélimumab | 2014 | Substitution F126L |
| G1e7 | védolizumab | 2014 | Substitutions L235A et G237A |
| G1e8 | atézolizumab | 2016 | Substitution N297A |
| G1e9 | durvalumab | 2017 | Substitutions L234F, L235E, P331S |
| G1e10 | risankizumab | 2019 | Substitutions L234A, L235A, et délétion 447K |
| G1e11 | eptinézumab | 2019 | Substitutions K213A et N297A |
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