Figure 1.
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États naïf et amorcé de pluripotence chez la souris. E4,5 et E6,5 représentent les stades de développement embryonnaire en jours. ES, embryonic stem ; EpiSC, epiblast stem cell ; LIF, leukemia inhibitory factor ; JAK, janus kinase ; STAT3, signal transducer and activator of transcription 3 ; GSK3i, inhibiteur pharmacologique de GSK3 (glycogen synthase kinase-3) ; MEKi, inhibiteur pharmacologique de MEK (mitogen-activated protein kinase kinase) ; SRK, Src-related kinases (Hck et Yes) ; FGF2, fibroblast growth factor 2 ; MAPK, mitogen-activated protein kinase ; PI3K, phosphoinositide 3-kinase ; 2nd X, second chromosome X.
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