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Tableau I.
Principales modifications post-traductionnelles (MPT) de type acétylation et méthylation des histones et leurs conséquences sur la transcription.
| Type d’histone | Acide aminé modifié | Modification | Abréviation | Conséquence |
|---|---|---|---|---|
| H3 | lysines 4, 9, 14, 18 | acétylation | H3ac | activation de la transcription |
| H4 | lysines 5, 8, 12, 16 | acétylation | H4ac | activation de la transcription |
| H3 | lysine 4 | méthylation | H3K4me | activation de la transcription |
| H3 | lysine 9 | méthylation | H3K9me | inhibe la transcription |
| H3 | lysine 27 | méthylation | H3K27me | inhibe la transcription |
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