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Tableau III.
Translocations impliquant le gène ALK rapportées chez les patients avec lymphome anaplasique à grandes cellules. Les données correspondent aux références [17, 55].
| Translocation | Gène partenaire | Fréquence |
|---|---|---|
| t(2;5)(p23;q35) | Nucleophosmin (NPM1) | 75 % |
| t(1;2)(q25;p23) | Tropomyosin 3 (TPM3) | 10-20 % |
| t(2;3)(p23;q11) | TRK fused gene (TFG) | 2-5 % |
| inv(2)(p23q35) | ATIC (Pur H gene) | 2-5 % |
| t(2;17)(p23;q23) | Clathrin heavy chain (CLTC) | 2-5 % |
| t(2;22)(p23;q11.2) | Myosin heavy chain (MYH9) | rare |
| t(2;17)(p23;q23) | ALK lymphoma oligomerization partner on chromosome 17 (ALO17) | rare |
| t(2;19)(p23;p13.1) | Tropomyosin 4 (TPM4) | rare |
| t(2;X)(p23;q11–12) | Moesin (MSN) | rare |
| t(2;9)(p23;q33.2) | Tumor necrosis factor receptor associated factor 1 (TRAF1) | rare |
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