Table II.
Bacteria which activate the different inflammasomes and their activating patterns. ESX-1: ESAT-6 secretion system 1; ESAT-6: 6-kDa early secreted antigenic target; YopJ: Yersinia outer protein J; Mxil: Max-interactor 1.
| Inflammasome | Bacteria | Activating pattern | References |
|---|---|---|---|
| NLRP1 | Bacillus anthracis | Lethal toxin | [35, 36] |
| NLRP3 | Burkholderia pseudomallei | BsaK | |
| Chlamydia pneumoniae | ? | ||
| Escherichia coli | mRNA | [22] | |
| Streptococcus B | Haemolysin-β | [23] | |
| Listeria monocytogenes | Lysteriolysin-O | ||
| Mycobacterium tuberculosis | ESX-1, ESAT-6 | ||
| Staphylococcus aureus | Haemolysin-α | [22] | |
| Streptococcus pneumoniae | Pneumolysin | ||
| Vibrio cholera | Cholera toxin-B | ||
| Yersinia pestis | Type 3 secretion system, YopJ | ||
| Neisseria gonorrhoeae | ? | ||
| Treponema denticola | Td92 | ||
| Leptospira interrogans | Glycolipoprotein | ||
| NLRP7 | Mycoplasma spp | Acylated lipopeptide | |
| NLRP12 | Yersinia pestis | ? | [40] |
| NLRC4 | Burkholderia pseudomallei | BsaK | |
| Escherichia coli | EprJ, EscI | ||
| Legionella pneumophila | Flagellin | [27, 33] | |
| Pseudomonas aeruginosa | Flagellin, PscL | ||
| Salmonella typhimurium | Type 3 secretion system, flagellin, PrgJ | ||
| Shigella flexneri | Mxil | ||
| Yersinia pestis | Type 3 secretion system | ||
| AIM2 | Francisella tularensis | DNA | [41] |
| Listeria monocytogenes | DNA | ||
| Mycobacterium tuberculosis | DNA |
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