| Issue |
Med Sci (Paris)
Volume 42, Number 6-7, Juin-Juillet 2026
Chroniques génomiques
|
|
|---|---|---|
| Page(s) | 644 - 647 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/2026107 | |
| Published online | 17 juillet 2026 | |
Les « serial cloneurs » de Yamanashi
Serial cloners of Yamanashi
Biologiste moléculaire, généticien, Président d’Aprogène (association pour la promotion de la génomique), Marseille, France
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Abstract
Serial cloning of mice by nuclear transfer has been pursued for 20 years and almost 60 successive generations by a highly dedicated Japanese team. Cloning has been successful up to the 57th generation, although with increasing difficulty from generation 25 onward. Thorough phenotypic and molecular analysis of the successive clones reveals the progressive accumulation of a large number of point mutations and structural variants. This finding has several implications and underlines the necessity of sexual reproduction to ensure continued fitness in successive generations.
© 2026 médecine/sciences – Inserm
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