| Issue |
Med Sci (Paris)
Volume 40, Number 6-7, Juin-Juillet 2024
Chroniques génomiques
|
|
|---|---|---|
| Page(s) | 563 - 565 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/2024070 | |
| Published online | 08 July 2024 | |
L’ADN ancien parle de plus en plus
Ancient DNA speaks
Biologiste, généticien et immunologiste, Président d’Aprogène (Association pour la promotion de la Génomique), 13007 Marseille, France
Abstract
Many human DNA sequences have been obtained from ancient remains dating back from several millennia. However, these have low coverage and may contain many errors; this has limited their usefulness for many analyses, in particular the search for Identical By Descent (IBD) segments that is very powerful for detection of kinship. A new method, using imputation from database data and sophisticated statistical analysis, proves able to detect IBD segments (and thus parenthood) in low-quality DNA sequences from individuals linked only by sixth degree parenthood, opening a whole new field of investigation using ancient DNA.
© 2024 médecine/sciences – Inserm
Article publié sous les conditions définies par la licence Creative Commons Attribution License CC-BY (https://creativecommons.org/licenses/by/4.0), qui autorise sans restrictions l'utilisation, la diffusion, et la reproduction sur quelque support que ce soit, sous réserve de citation correcte de la publication originale.
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