Lycorine inhibits the proliferation of A375 cells in a dose- and time-dependent manner (CCK-8 assay). A. Effects of different doses of lycorine on A375 cell proiferation. B. Effect of 50 μM lycorine on HEMa cell (normal melanocytes) proliferation. C, Effects of 50 μM lycorine on A375 cell proliferation after lycorine treatment for different periods of time. All values are presented as means ± S.D. *P<0.05, ** P<0.01 compared with control group. n = 3 for each group.