JTC-801 regulates the biological behavior of M14 cells through the down-regulation of the PI3K-Akt-mTOR pathway. A. Phosphorylation levels of Akt, mTOR and expression level of p70S6K in M14 cells after treatment with JTC-801 (Western-blots). B. Histograms showing the differences (expressed as fold changes) observed in Westen-blot experiments shown in A (*, versus NC, P < 0.05, Student’s t test). N = 3 for each group.