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Figure 2.

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Représentation schématique du mécanisme des mutants SF3B1 reconnaissant des points de branchement (PB) alternatifs (PB’) et résultant en ARNm aberrants. mut : mutated; p14 : splicing factor 3B, 14 kDa subunit; SF3B1 : splicing factor 3B subunit 1; U2AF : U2 small nuclear RNA auxiliary factor 2; U2 snARN : U2 small nuclear RNA; U2AF 35 kDa (35) and 65 kDa (65) subunits.

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