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Tableau I.
Dynamique des Tfh observée dans différentes études. Bcl-6 : B-cell lymphoma 6 ; CCR : chemokine (C-C motif) receptor ; CXCR : chemokine (C-X-C motif) receptor ; PD-1 : programmed cell death 1 ; ND : non déterminé. « + » : le marqueur est exprimé ; « - » : le marqueur n’est pas exprimé.
| Virus | Stade | Progression | Organe | Phénotype | Dynamique | Réf. |
|---|---|---|---|---|---|---|
| VIH | Chronique | N.D. | Ganglions | CXCR5+PD-1+ Bcl-6+ | Accumulation | [21] |
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| VIH | Chronique | N.D. | Ganglions | CXCR5+PD-1+ Bcl-6+ (CCR7-CD45RA-) | Accumulation | [26] |
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| SIV | Précoce | Progresseurs | Rate | CXCR5+PD-1+ | Perte | [31] |
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| SIV | Précoce | Progresseurs lents | Ganglions | CXCR5+PD-1+ | Accumulation | [32] |
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| SIV | Précoce | Progresseurs rapides | Ganglions | CXCR5+PD-1+ | Pas d’accumulation | [32] |
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| SIV | Chronique | Progresseurs lents | Ganglions | CXCR5+PD-1+ | Accumulation | [30] |
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| SIV | Chronique | Progresseurs lents | RateGanglions | CD45RA-CD62L+ CXCR5+PD-1+ | Accumulation | [31] |
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| SIV | Chronique | Progresseurs rapides | Ganglions | CXCR5+PD-1+ | Perte | [31] |
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| SIV | Sida | Progresseurs | Ganglions | CXCR5+PD-1+ | Perte | [52] |
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| SIV | Chronique | Contrôleurs | Ganglions | CXCR5+PD-1+ | Préservation | [52] |
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| SIV | Chronique | Progresseurs | Ganglions | CXCR5+PD-1+ | Accumulation | [28] |
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| SIV | Chronique | ND | Ganglions | CD28fortCD95fort CCR7faiblePD-1fort | Accumulation | [29] |
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