Figure 1.
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La coopération entre la fusion EWSR1-FLI1 et un polymorphisme du microsatellite mSat2 aboutit à une surexpression de EGR2 et à une prolifération accrue dans le sarcome d’Ewing. EGR2 : early growth response 2 ; EWSR1 : Ewing sarcoma breakpoint region 1 ; FLI1 : Friend leukemia virus integration 1 ; GGAA : motif microsatellite de répétition guanosine-guanosine-adénine-adénine ; GGAT : motif microsatellite de répétition guanosine-guanosine-adénine-thymine ; mSat2 : zone GGAA, cible de fixation de EWSR1-FLI1.
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