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Tableau I.
Conversion directe de cellules gliales et péricytes en neurones in vitro.
| Cellule d’origine | Facteurs de transcription | Phénotype des neurones induits | Références |
|---|---|---|---|
| Astrocyte murin | Pax6 | Sans phénotype caractérisé | [26, 2] |
| Neurog2 | Glutamatergique | [28, 29, 31] | |
| Dlx2 | GABAergique | [28, 29] | |
| Dlx2, Ascl1 | GABAergique | [28, 29] | |
| Ascl1, Lmx1b, Nurr1 | Dopaminergique | [32] | |
| NeuroD1 | Glutamatergique | [33] | |
| Astrocyte humain | NeuroD1 | Glutamatergique | [33] |
| Cellules gliales NG2 murines | Neurog2 | Glutamatergique | [31] |
| NeuroD1 | Glutamatergique et GABAergique | [33] | |
| Péricyte humain | Ascl1, Sox2 | GABAergique | [34] |
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