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Tableau III.

Principaux médiateurs et récepteurs impliqués dans le prurit.

Classes Médiateurs Récepteurs
Neuromédiateurs AcétylcholineBradykinineCGRPEndorphines M3B1, B2CGRP-RMOR (m-opioid receptor),DOR (d-opioid receptor)

EnképhalinesHistamineSérotonineSomatostatineSubstance PVIP MOR, DORH1 (H2)5-HT2SSTNK1, NK2, NK3VPAC1

Protéases Cathepsine SKallicréinesMucunaïne (cowhage)PapaïneTrypsineTryptase PAR-2, PAR-4PAR-2PAR-2, PAR-4PAR-2PAR-2PAR-2

Eïcosanoïdes/lipides Acide lysophosphatidiqueAcides biliairesLeucotriène B4Prostaglandine E2 ?TGR5LTB4R1EP2

Cytokines Interféron Interleukine 2Interleukine 31 IFNGRIL2-RIL31-R

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