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Tableau III.
Principaux médiateurs et récepteurs impliqués dans le prurit.
| Classes | Médiateurs | Récepteurs |
|---|---|---|
| Neuromédiateurs | AcétylcholineBradykinineCGRPEndorphines | M3B1, B2CGRP-RMOR (m-opioid receptor),DOR (d-opioid receptor) |
| EnképhalinesHistamineSérotonineSomatostatineSubstance PVIP | MOR, DORH1 (H2)5-HT2SSTNK1, NK2, NK3VPAC1 | |
| Protéases | Cathepsine SKallicréinesMucunaïne (cowhage)PapaïneTrypsineTryptase | PAR-2, PAR-4PAR-2PAR-2, PAR-4PAR-2PAR-2PAR-2 |
| Eïcosanoïdes/lipides | Acide lysophosphatidiqueAcides biliairesLeucotriène B4Prostaglandine E2 | ?TGR5LTB4R1EP2 |
| Cytokines | Interféron Interleukine 2Interleukine 31 | IFNGRIL2-RIL31-R |
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