Figure 1.
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Structure of the inflammasome. A. Structure of the different proteins involved in inflammasome formation. B. The inflammasome NLRP3 comprises an NLRP3 receptor, an ASC adaptor, and procaspase-1. PYD: pyrin domain; NBD: nucleotide binding domain (allows ATP-dependent oligomerisation of NLRs); LRR: leucine-rich repeats; FIIND: function to find domain; CARD: caspase activation and recruitment domain; RD: repression domain.
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