Figure 2.
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Fonctions pléiotropes d’Akt. La sérine-thréonine kinase Akt activée en aval de la PI3K régule de multiples cibles cellulaires impliquées dans le contrôle de la survie et de la prolifération cellulaire. PIP2 : phosphatidylinositol-(4,5)-biphosphate ; PIP3 : phosphatidylinositol-(3,4,5)-triphosphate ; PH : pleckstrin homology ; GEF : guanine nucleotide exchange factor ; IKK : I kappa B kinase complex.
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