Contrôle de l’expression de Bcl-xL par les facteurs de transcription Ets

Arnaud Zaldumbide; Lidia Sevilla; Philippe Pognonec; Kim E. Boulukos

doi:doi:10.1051/medsci/200117121356

Accès gratuit

Numéro		Med Sci (Paris) Volume 17, Numéro 12, Décembre 2001


Page(s)		1356 - 1357
Section		Nouvelles et Brèves
DOI		http://dx.doi.org/10.1051/medsci/200117121356
Publié en ligne		15 December 2001

Ghysdael J, Boureux A. The ETS family of transcriptional regulators In : Yaniv, M. and Ghysdael, J., eds. Oncogenes as Transcriptional Regulators : Retroviral Oncogenes. Basel : Birkhauser, 1997 : 29–88.
Pognonec P, Boulukos KE, Gegonne A, Bailly M, Stéhelin D, Ghysdael J. Identification and differential expression of the proteins encoded by the c-ets-1 and c-ets-2 protooncogenes. Arch Int Physiol Bioch 1987; 96 : B51.
Pognonec P, Boulukos KE, Gesquière JC, Stéhelin D, Ghysdael J. Mitogenic stimulation of thymocytes results in the calcium-dependent phosphorylation of c-Ets-1 proteins. EMBO J 1988; 7 : 977–83.
Sevilla L, Zaldumbide A, Carlotti F, et al. Bcl-x_L expression correlates with primary macrophage differentiation, activation of functional competence and survival, and results from synergistic transcriptional activation by Ets2 and PU.1. J Biol Chem 2001; 276 : 17800–7.
Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 1994; 265 : 1573–7.
McKercher S, Torbett B, Anderson K, et al. Targetted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J 1996; 15: 5647–58.
Motoyama N, Wang F, Roth KA, et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 1995; 267 : 1506–10.
Packham G, White EL, Eischen CM, et al. Selective regulation of Bcl-x_L by a Jak kinasedependent pathway is bypassed in murine hematopoietic malignancies. Genes Dev 1998; 12 : 2475–87.
Sevilla L, Aperlo C, Dulic V, et al. The Ets2 transcription factor inhibits apoptosis induced by CSF-1 deprivation of macrophages through a Bcl-x_L-dependent mechanism. Mol Cell Biol 1999; 19 : 2624–34.
Grillot DA, Gonzalez-Garcia M, Ekhterae D, et al. Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. J Immunol 1997; 158 : 4750–7.
Chang BS, Kelekar A, Harris MH, Harlan JE, Fesik SW, Thompson CA. The BH3 domain of Bcl-x(S) is required for inhibition of the antiapoptotic function of Bcl-x(L). Mol Cell Biol 1999; 19: 6673–81.
Sevilla L, Zaldumbide A, Pognonec P, Boulukos KE. Transcriptional regulation of the bcl-x gene encoding the anti-apoptotic Bcl-x_L protein by Ets, Rel/NFkB, STAT and AP1 transcription factor families. Histol Histopathol 2001; 16 : 595–601.

[1] Ghysdael J, Boureux A. The ETS family of transcriptional regulators In : Yaniv, M. and Ghysdael, J., eds. Oncogenes as Transcriptional Regulators : Retroviral Oncogenes. Basel : Birkhauser, 1997 : 29–88.

[2] Pognonec P, Boulukos KE, Gegonne A, Bailly M, Stéhelin D, Ghysdael J. Identification and differential expression of the proteins encoded by the c-ets-1 and c-ets-2 protooncogenes. Arch Int Physiol Bioch 1987; 96 : B51.

[3] Pognonec P, Boulukos KE, Gesquière JC, Stéhelin D, Ghysdael J. Mitogenic stimulation of thymocytes results in the calcium-dependent phosphorylation of c-Ets-1 proteins. EMBO J 1988; 7 : 977–83.

[4] Sevilla L, Zaldumbide A, Carlotti F, et al. Bcl-x_L expression correlates with primary macrophage differentiation, activation of functional competence and survival, and results from synergistic transcriptional activation by Ets2 and PU.1. J Biol Chem 2001; 276 : 17800–7.

[5] Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 1994; 265 : 1573–7.

[6] McKercher S, Torbett B, Anderson K, et al. Targetted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J 1996; 15: 5647–58.

[7] Motoyama N, Wang F, Roth KA, et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 1995; 267 : 1506–10.

[8] Packham G, White EL, Eischen CM, et al. Selective regulation of Bcl-x_L by a Jak kinasedependent pathway is bypassed in murine hematopoietic malignancies. Genes Dev 1998; 12 : 2475–87.

[9] Sevilla L, Aperlo C, Dulic V, et al. The Ets2 transcription factor inhibits apoptosis induced by CSF-1 deprivation of macrophages through a Bcl-x_L-dependent mechanism. Mol Cell Biol 1999; 19 : 2624–34.

[10] Grillot DA, Gonzalez-Garcia M, Ekhterae D, et al. Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. J Immunol 1997; 158 : 4750–7.

[11] Chang BS, Kelekar A, Harris MH, Harlan JE, Fesik SW, Thompson CA. The BH3 domain of Bcl-x(S) is required for inhibition of the antiapoptotic function of Bcl-x(L). Mol Cell Biol 1999; 19: 6673–81.

[12] Sevilla L, Zaldumbide A, Pognonec P, Boulukos KE. Transcriptional regulation of the bcl-x gene encoding the anti-apoptotic Bcl-x_L protein by Ets, Rel/NFkB, STAT and AP1 transcription factor families. Histol Histopathol 2001; 16 : 595–601.

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