L’adiponectine détrônera-t-elle la leptine ?

Michèle Guerre-Millo

doi:doi:10.1051/medsci/200117121353

Accès gratuit

Numéro		Med Sci (Paris) Volume 17, Numéro 12, Décembre 2001


Page(s)		1353 - 1354
Section		Nouvelles et Brèves
DOI		http://dx.doi.org/10.1051/medsci/200117121353
Publié en ligne		15 December 2001

Matsuzawa Y, Funahashi T, Nakamura T. Molecular mechanism of metabolic syndrome X : contribution of adipocytokines adipocyte-derived bioactive substances. Ann NY Acad Sci 1999; 892 : 146–54.
Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995; 270: 26746–9.
Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996; 271: 10697–703.
Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem (Tokyo) 1996; 120: 803–12.
Hotta K, Funahashi T, Bodkin NL, et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001; 50: 1126–33.
Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes : close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001; 86 : 1930–5.
Fruebis J, Tsao TS, Javorschi S, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 2001; 98 : 2005–10.
Yamauchi T, Kamon J, Waki H, et al. The fatderived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001; 7 : 941–6.
Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001; 7 : 947–53.
Ouchi N, Kihara S, Arita Y, et al. Novel modulator for endothelial adhesion molecules : adipocyte-derived plasma protein adiponectin. Circulation 1999; 100 : 2473–6.
Yokota T, Oritani K, Takahashi I, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 2000; 96 : 1723–32.
Sato C, Yasukawa Z, Honda N, Matsuda T, Kitajima K. Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q. J Biol Chem 2001; 276 : 28849–56.
Patel N, Brinkman-Van der Linden EC, Altmann SW, et al. OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. J Biol Chem 1999; 274 : 22729–38.
Maeda N, Takahashi M, Funahashi T, et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001; 50 : 2094–9.

[1] Matsuzawa Y, Funahashi T, Nakamura T. Molecular mechanism of metabolic syndrome X : contribution of adipocytokines adipocyte-derived bioactive substances. Ann NY Acad Sci 1999; 892 : 146–54.

[2] Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995; 270: 26746–9.

[3] Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996; 271: 10697–703.

[4] Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem (Tokyo) 1996; 120: 803–12.

[5] Hotta K, Funahashi T, Bodkin NL, et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001; 50: 1126–33.

[6] Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes : close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001; 86 : 1930–5.

[7] Fruebis J, Tsao TS, Javorschi S, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 2001; 98 : 2005–10.

[8] Yamauchi T, Kamon J, Waki H, et al. The fatderived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001; 7 : 941–6.

[9] Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001; 7 : 947–53.

[10] Ouchi N, Kihara S, Arita Y, et al. Novel modulator for endothelial adhesion molecules : adipocyte-derived plasma protein adiponectin. Circulation 1999; 100 : 2473–6.

[11] Yokota T, Oritani K, Takahashi I, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 2000; 96 : 1723–32.

[12] Sato C, Yasukawa Z, Honda N, Matsuda T, Kitajima K. Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q. J Biol Chem 2001; 276 : 28849–56.

[13] Patel N, Brinkman-Van der Linden EC, Altmann SW, et al. OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. J Biol Chem 1999; 274 : 22729–38.

[14] Maeda N, Takahashi M, Funahashi T, et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001; 50 : 2094–9.

Prix Nobel 2012