Accès gratuit
Med Sci (Paris)
Volume 18, Numéro 1, Janvier 2002
Page(s) 23 - 25
Section Le Magazine : Nouvelles
Publié en ligne 15 janvier 2002
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  2. Stickens D, Clines G, Burbee D, et al. The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes. Nat Genet 1996; 14 : 25–32.
  3. McCormick G, Leduc Y, Martindale D, et al. The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate. Nat Genet 1998; 19 : 158–61.
  4. Kitagawa H, Shimakawa H, Sugahara K. The tumor suppressor EXT-like gene EXTL2 encodes an alpha1,4-N-acetylhexosaminyltransferase that transfers N-acetylga-actosamine and N-acetyl-glucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate. J Biol Chem 1999; 274 :13933–7.
  5. Mc Cormick, Duncan G, Goutsos T, Tufaro F. The putative tumor suppressors EXT1 and EXT 2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate. Proc Natl Acad Sci USA 2000; 97 : 668–73.
  6. Wei G, Bai X, Bame KJ, Koshy TI, Spear PG, Esko JD. Location of the glucurono-syltransferase domain in the heparan sulfate copolymerase EXT1 by analysis of Chinese hamster ovary cells. J Biol Chem 2000; 275 : 27733–40.
  7. Francannet C, Cohen-Tanugi A, LeMerrer M, Munnich A, Bonaventure J, Legeai-Mallet L. Genotype-phenotype correlation in hereditary multiple exostoses. J Med Genet 2001; 38 : 430–4.
  8. Lin X, Wei G, Shi Z, et al. Disruption of gastrulation and heparan sulfate biosyn-thesis in EXT1 deficient mice. Dev Biol 2000; 224 : 299–311.
  9. Bellaiche Y, The I, Perrimon N. Tout-velu is a Drosophila homologue of the putative tumour suppressor Ext1 and is needed for Hh diffusion. Nature 1998; 394 : 85–8.
  10. Chung UI, Schipani E, McMahon AP, Kronenberg HM. Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest 2001; 107 : 295–304.
  11. Ducy P, Contrôle génétique de la squelettogenèse. Med Sci 2001; 17 : 1242–51
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  13. Duncan G, McCormick C, Tufaro F. The link between heparan sulfate and hereditary bone disease : finding a function for the EXT family of putative suppressor tumor proteins. J Clin Invest 2001; 108 : 511–6.

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