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Figure 1.

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Vue schématique de la paroi de Mycobacterium abscessus et mode d’action des inhibiteurs de MmpL3. (A) EJMCh-6 et BMC-2i inhibent le transport du tréhalose mono-mycolate (TMM), qui sert de substrat aux protéines du complexe Ag85 pour mycolyler l’arabinogalactane ou produire du tréhalose di-mycolate (TDM), qui s’insère dans la membrane bactérienne externe. (B) Structure du TMM.

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