Free Access
Tableau I.
Principaux marqueurs moléculaires de la différenciation germinale
| Stade d’expression | Gène | Signification des abréviations | Références | |
|---|---|---|---|---|
| Marqueurs communs | Pluripotence | SSEA1/3/4 | Stage specific embryonic antigen 1/3 | [5, 7, 13, 16, 17, 22, 23] |
| TRA-1-60 | [7, 16, 22] | |||
| TRA-1-81 | [5, 22] | |||
| PGC migratoires | CXCR4 | Chemokine (C-X-C motif) receptor 4 | [7] | |
| Pluripotence, préméiotique | POU5F1 (OCT3/4) | POU class 5 homeobox 1 | [5, 8, 12, 15–17, 19, 20, 22–25, 27, 28] | |
| Nanog | Nanog homeobox | [5, 7, 8, 15, 16, 22] | ||
| Préméiotique (cellules germinales prémigratoires) | STELLA (DPPA3) | Developmental pluripotency associated 3 | [5, 7, 8, 12, 15, 17–20, 22, 24, 25, 28] | |
| Préméiotique | GDF3 | Growth differentiation factor 3 | [5] | |
| Préméiotique, testicule spécifique, ovaire fœtal | STRA8 | Stimulated by retinoic acid gene 8 | [18, 19, 24, 28] | |
| Méiotique précoce | SCP1/3 (SYCP1/3) | Synaptonemal complex protein 1/3 | [5, 8, 15, 16, 18–20, 23, 25, 27, 28] | |
| DMC1 | Meiosis-specific homologous recombination gene | [19, 27] | ||
| Pré et postméiotique | NANOS1 | Nanos homolog 1 | [5, 15] | |
| VASA (DDX4, MVH) | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | [5, 7, 8, 13, 15, 16, 19, 20, 22, 24, 25, 27, 28] | ||
| DAZL (DAZ, BOULE) | Deleted in azoospermia-like | [5, 7, 8, 15–19, 24, 28,] | ||
| PUM1/2 | Pumilio homolog 1 | [5, 15] | ||
| Méiotique | MLH1 | MutL homolog 1, colon cancer, nonpolyposis type 2 | [5, 15, 28] | |
| Méiotique tardif | TRIM36 (HAPRIN) | Tripartite motif-containing 36 | [17] | |
| Germinal précoce | PRDM1 (BLIMP1) | PR domain containing 1, with ZNF domain | [7, 8, 12, 13, 28] | |
| Germinal précoce et tardif | KIT | V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | [5, 7, 13, 16, 19, 22, 24, 25, 27] | |
| Cellules Sertoli, cellules Leydig, cellules de la granulosa, cellules de la thèque | FSHR/LHR | Follicle stimulating hormone receptor/ luteinizing hormone receptor | [7, 8, 17] | |
| Cellules Sertoli, cellules de la granulosa | AMH (MIS) | Anti-Mullerian hormone | [7, 8, 13, 17] | |
| IFITM3 (FGLS) | Interferon induced transmembrane protein 3 | [12, 15, 17, 19, 20, 25] | ||
| Marqueurs mâles | Différenciation mâle | SRY | Sex determining region Y | [13, 17, 20] |
| Spermatide | TNP1/2 | Transition nuclear protein 1/2 | [16, 19] | |
| Méiotique tardif, stade spermatocyte et spermatide ronde | TEKT1 | Tektin 1 | [5] | |
| Méiotique tardif, spermatozoïde mature | ACR | Acrosin | [7, 8, 17, 19] | |
| Postméiotique | PRM1/2 | Protamine 1/2 | [16, 18, 19] | |
| Spermiogenèse | ACT | Activator of CREM in testis | [18] | |
| Cellules Sertoli | SOX9 | SRY (sex determining region Y)-box 9 | [7, 8] | |
| Marqueurs femelles | Ovocyte | FIGLA (Fig α ) | Folliculogenesis specific basic helix-loop-helix | [19, 24, 25, 27] |
| Ovocyte | GDF9 | Growth differentiation factor 9 | [5, 16, 22, 25, 27, 29] | |
| Germinal tardif, ovocyte | ZPA/C (ZAP1/3) | Zona pellucida glycoprotein (sperm receptor) A/C | [16, 24, 25, 27, 29] | |
| Cellules folliculaires | STAR | Steroidogenic acute regulatory protein | [27] | |
| Cellules de la granulosa | CYP19A1 (AROMATASE) | P450, family 19, subfamily A, polypeptide 1 | [13, 27] | |
| Cellules de la thèque | Cyp17A1 (cytochrome P450) | P450, family 17, subfamily A, polypeptide 1 | [27] | |
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.