FcRn, un récepteur d’IgG aux multiples facettes

Charlotte Magdelaine-Beuzelin; Marc Ohresser; Hervé Watier

doi:doi:10.1051/medsci/200925121053

Accès gratuit

Numéro		Med Sci (Paris) Volume 25, Numéro 12, Décembre 2009 Anticorps monoclonaux en thérapeutique


Page(s)		1053 - 1056
Section		I - De la conception à la production
DOI		http://dx.doi.org/10.1051/medsci/200925121053
Publié en ligne		15 December 2009

Ransom DR. Prophylactic effect of antitoxin on the child in utero. J Am Med Ass 1909; Iii : 556.
Brambell FWR, Hemmings WA, Morris IG. A theoretical model of γ-globulin catabolism. Nature 1964; 203 : 1352–5.
Brambell FWR. The transmission of immune globulins from the mother to the fœtal and newborn young. Proc Nutr Soc 1969; 28 : 35–41.
Simister NE, Mostov KE. An Fc receptor structurally related to MHC class I antigens. Nature 1989; 337 : 184–7.
Martin WL, West AP Jr, Gan L, Bjorkman PJ. Crystal structure at 2.8 Å of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding. Mol Cell 2001; 7 : 867–77.
Vidarsson G, Stemerding AM, Stapleton NM, et al. FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis. Blood 2006; 108 : 3573–9.
Anderson CL, Chaudhury C, Kim J, et al. Perspective-FcRn transports albumin: relevance to immunology and medicine. Trends Immunol 2006; 27 : 343–8.
McCarthy KM, Lam M, Subramanian L, et al. Effects of mutations in potential phosphorylation sites on transcytosis of FcRn. J Cell Sci 2001; 114 : 1591–8.
Roopenian DC, Akilesh S. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 2007; 7 : 715–25.
Ober RJ, Radu CG, Ghetie V. Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. Int Immunol 2001; 13 : 1551–9.
Datta-Mannan A, Witcher DR, Tang Y, et al. Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor. J Biol Chem 2007; 282 : 1709–17.

[1] Ransom DR. Prophylactic effect of antitoxin on the child in utero. J Am Med Ass 1909; Iii : 556.

[2] Brambell FWR, Hemmings WA, Morris IG. A theoretical model of γ-globulin catabolism. Nature 1964; 203 : 1352–5.

[3] Brambell FWR. The transmission of immune globulins from the mother to the fœtal and newborn young. Proc Nutr Soc 1969; 28 : 35–41.

[4] Simister NE, Mostov KE. An Fc receptor structurally related to MHC class I antigens. Nature 1989; 337 : 184–7.

[5] Martin WL, West AP Jr, Gan L, Bjorkman PJ. Crystal structure at 2.8 Å of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding. Mol Cell 2001; 7 : 867–77.

[6] Vidarsson G, Stemerding AM, Stapleton NM, et al. FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis. Blood 2006; 108 : 3573–9.

[7] Anderson CL, Chaudhury C, Kim J, et al. Perspective-FcRn transports albumin: relevance to immunology and medicine. Trends Immunol 2006; 27 : 343–8.

[8] McCarthy KM, Lam M, Subramanian L, et al. Effects of mutations in potential phosphorylation sites on transcytosis of FcRn. J Cell Sci 2001; 114 : 1591–8.

[9] Roopenian DC, Akilesh S. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 2007; 7 : 715–25.

[10] Ober RJ, Radu CG, Ghetie V. Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. Int Immunol 2001; 13 : 1551–9.

[11] Datta-Mannan A, Witcher DR, Tang Y, et al. Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor. J Biol Chem 2007; 282 : 1709–17.

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