Augmentation paradoxale du nombre de synapses glutamatergiques lors des troubles cognitifs légers de la maladie d’Alzheimer

Karen F.S. Bell; A. Claudio Cuello

doi:doi:10.1051/medsci/20082410807

Accès gratuit

Numéro		Med Sci (Paris) Volume 24, Numéro 10, Octobre 2008


Page(s)		807 - 810
Section		Nouvelles
DOI		http://dx.doi.org/10.1051/medsci/20082410807
Publié en ligne		15 October 2008

DeKosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer’s disease: correlation with cognitive severity. Ann Neurol 1990; 27 : 457–64.
Terry RD, Masliah E, Salmon DP, et al. Physical basis of cognitive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991; 30 : 572–80.
Geddes JW, Monaghan DT, Cotman CW, et al. Plasticity of hippocampal circuitry in Alzheimer’s disease. Science 1985; 230 : 1179–81.
Geddes JW, Anderson KJ, Cotman CW. Senile plaques as aberrant sprout-stimulating structures. Exp Neurol 1986; 94 : 767–76.
McKee AC, Kosik KS, Kowall NW. Neuritic pathology and dementia in Alzheimer’s disease. Ann Neurol 1991; 30 : 156–65.
Bell KF, de Kort GJ, Steggerda S, et al. Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. Neurosci Lett 2003; 353 : 143–7.
Bell KF, Ducatenzeiler A, Ribeiro da Silva A, et al. The amyloid pathology progresses in a neurotransmitter-specific manner. Neurobiol Aging 2006; 27 : 1644–57.
Bell KF, Bennett DA, Cuello AC. Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment. J Neurosci 2007; 27 : 10810–7.
DeKosky ST, Ikonomovic MD, Styren SD, et al. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol 2002; 51 : 145–55.
Ikonomovic MD, Mufson EJ, Wuu J, et al. Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer’s neuropathology. J Alzheimer Dis 2003; 5: 39–48.
Bell KFS, Cuello AC Altered synaptic function in Alzheimer’s disease. Eur J Pharmacol 2006; 545 : 11–21.

[1] DeKosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer’s disease: correlation with cognitive severity. Ann Neurol 1990; 27 : 457–64.

[2] Terry RD, Masliah E, Salmon DP, et al. Physical basis of cognitive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991; 30 : 572–80.

[3] Geddes JW, Monaghan DT, Cotman CW, et al. Plasticity of hippocampal circuitry in Alzheimer’s disease. Science 1985; 230 : 1179–81.

[4] Geddes JW, Anderson KJ, Cotman CW. Senile plaques as aberrant sprout-stimulating structures. Exp Neurol 1986; 94 : 767–76.

[5] McKee AC, Kosik KS, Kowall NW. Neuritic pathology and dementia in Alzheimer’s disease. Ann Neurol 1991; 30 : 156–65.

[6] Bell KF, de Kort GJ, Steggerda S, et al. Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. Neurosci Lett 2003; 353 : 143–7.

[7] Bell KF, Ducatenzeiler A, Ribeiro da Silva A, et al. The amyloid pathology progresses in a neurotransmitter-specific manner. Neurobiol Aging 2006; 27 : 1644–57.

[8] Bell KF, Bennett DA, Cuello AC. Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment. J Neurosci 2007; 27 : 10810–7.

[9] DeKosky ST, Ikonomovic MD, Styren SD, et al. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol 2002; 51 : 145–55.

[10] Ikonomovic MD, Mufson EJ, Wuu J, et al. Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer’s neuropathology. J Alzheimer Dis 2003; 5: 39–48.

[11] Bell KFS, Cuello AC Altered synaptic function in Alzheimer’s disease. Eur J Pharmacol 2006; 545 : 11–21.

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