Deux ans après, l’activationinduced cytidine deaminase n’a pas livré tous ses secrets

Nadia Catalan; Kohsuke Imai; Patrick Revy; Alain Fischer; Anne Durandy

doi:doi:10.1051/medsci/2003192139

Accès gratuit

Numéro		Med Sci (Paris) Volume 19, Numéro 2, Février 2003


Page(s)		139 - 141
Section		Le Magazine : Nouvelles
DOI		http://dx.doi.org/10.1051/medsci/2003192139
Publié en ligne		15 February 2003

Revy P, Muto T, Levy Y, et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 2000; 102: 565–75.
Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000; 102: 553–63.
Nagaoka H, Muramatsu M, Yamamura N, Kinoshita K, Honjo T. Activationinduced deaminase (AID)- directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation. J Exp Med 2002; 195: 529–34.
Wuerffel RA, Du J, Thompson RJ, Kenter AL. IgS gamma3 DNA-specifc double strand breaks are induced in mitogenactivated B cells and are implicated in switch recombination. J Immunol 1997; 159: 4139–44.
Bross L, Fukita Y, McBlane F, Demolliere C, Rajewsky K, Jacobs H. DNA doublestrand breaks in immunoglobulin genes undergoing somatic hypermutation. Immunity 2000; 13: 589–97.
Papavasiliou FN, Schatz DG. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature 2000; 408: 216–21.
Bross L, Muramatsu M, Kinoshita K, Honjo T, Jacobs H. DNA doublestrand breaks: prior to but not sufficient in targeting hypermutation. J Exp Med 2002; 195: 1187–92.
Papavasiliou FN, Schatz DG. The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process. J Exp Med 2002; 195: 1193–8.
Faili A, Aoufouchi S, Gueranger Q, et al. AIDdependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line. Nat Immunol 2002; 3: 815–21.
Petersen S, Casellas R, Reina-San-Martin B, et al. AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature 2001; 414: 660–5.
Blanc V, Farré JC, Litvak S, Araya A. Réécriture du matériel génétique: fonctions et mécanismes de l’édition de l’ARN. Med Sci 2002; 18: 181–92.
Okazaki IM, Kinoshita K, Muramatsu M, Yoshikawa K, Honjo T. The AID enzyme induces class switch recombination in fibroblasts. Nature 2002; 416: 340–5.
Petersen-Mahrt SK, Harris RS, Neuberger MS. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 2002; 418: 99–104.
Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol 2002; 12: 1748–55.
Faili A, Aoufouchi S, Flatter E, Gueranger Q, Reynaud CA, Weill JC. Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota. Nature 2002; 419: 944–7.
Harris RS, Petersen-Mahrt SK, Neuberger MS. RNA editing enzyme apobec1 and some of its homologs can act as DNA mutators. Mol Cell 2002; 10: 1247–53.

[1] Revy P, Muto T, Levy Y, et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 2000; 102: 565–75.

[2] Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000; 102: 553–63.

[3] Nagaoka H, Muramatsu M, Yamamura N, Kinoshita K, Honjo T. Activationinduced deaminase (AID)- directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation. J Exp Med 2002; 195: 529–34.

[4] Wuerffel RA, Du J, Thompson RJ, Kenter AL. IgS gamma3 DNA-specifc double strand breaks are induced in mitogenactivated B cells and are implicated in switch recombination. J Immunol 1997; 159: 4139–44.

[5] Bross L, Fukita Y, McBlane F, Demolliere C, Rajewsky K, Jacobs H. DNA doublestrand breaks in immunoglobulin genes undergoing somatic hypermutation. Immunity 2000; 13: 589–97.

[6] Papavasiliou FN, Schatz DG. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature 2000; 408: 216–21.

[7] Bross L, Muramatsu M, Kinoshita K, Honjo T, Jacobs H. DNA doublestrand breaks: prior to but not sufficient in targeting hypermutation. J Exp Med 2002; 195: 1187–92.

[8] Papavasiliou FN, Schatz DG. The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process. J Exp Med 2002; 195: 1193–8.

[9] Faili A, Aoufouchi S, Gueranger Q, et al. AIDdependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line. Nat Immunol 2002; 3: 815–21.

[10] Petersen S, Casellas R, Reina-San-Martin B, et al. AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature 2001; 414: 660–5.

[11] Blanc V, Farré JC, Litvak S, Araya A. Réécriture du matériel génétique: fonctions et mécanismes de l’édition de l’ARN. Med Sci 2002; 18: 181–92.

[12] Okazaki IM, Kinoshita K, Muramatsu M, Yoshikawa K, Honjo T. The AID enzyme induces class switch recombination in fibroblasts. Nature 2002; 416: 340–5.

[13] Petersen-Mahrt SK, Harris RS, Neuberger MS. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 2002; 418: 99–104.

[14] Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol 2002; 12: 1748–55.

[15] Faili A, Aoufouchi S, Flatter E, Gueranger Q, Reynaud CA, Weill JC. Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota. Nature 2002; 419: 944–7.

[16] Harris RS, Petersen-Mahrt SK, Neuberger MS. RNA editing enzyme apobec1 and some of its homologs can act as DNA mutators. Mol Cell 2002; 10: 1247–53.

Prix Nobel 2012