m/s was founded in 1985 as the result of the cooperation between the French and Quebec governments, to support the "promotion of French language for the diffusion of scientific and medical culture". m/s was initially implemented both by Inserm (the French National Institute of Health and Medical Research), a public institute which operates under the joint authority of the French Ministry of Health and the French Ministry of Research) and SRMS (la Société de la revue médecine/sciences) in Quebec.
Since 2006, m/s is owned exclusively by Inserm, which delegated the management to EDK, which has joined the group EDP Sciences, under a public service delegation agreement.
m/s is one of Inserm’s preferred media for the dissemination of knowledge. Its editorial team is composed of Inserm researchers or directors of Inserm laboratories dedicated to m/s.