Rac1 est la cible de l’activité E3 ubiquitine-ligase du suppresseur de tumeur HACE1

Gérard Gacon; Amel Mettouchi; Emmanuel Lemichez

doi:doi:10.1051/medsci/2012281014

Accès gratuit

Numéro		Med Sci (Paris) Volume 28, Numéro 1, Janvier 2012


Page(s)		39 - 41
Section		Nouvelles
DOI		http://dx.doi.org/10.1051/medsci/2012281014
Publié en ligne		27 January 2012

Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 2008 ; 9 : 690–701. [CrossRef] [PubMed]
Boquet P, Lemichez E. Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis? Trends Cell Biol 2003 ; 13 : 238–246. [CrossRef] [PubMed]
Torrino S, Visvikis O, Doye A, et al. The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1. Dev Cell 2011 ; 21 : 959–965. [CrossRef] [PubMed]
Visvikis O, Maddugoda MP, Lemichez E. Direct modifications of Rho proteins: deconstructing GTPase regulation. Biol Cell 2010 ; 102 : 377–389. [CrossRef] [PubMed]
Doye A, Mettouchi A, Bossis G, et al. CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion. Cell 2002 ; 111 : 553–564. [CrossRef] [PubMed]
Visvikis O, Boyer L, Torrino S, et al. Escherichia coli producing CNF1 toxin hijacks tollip to trigger Rac1-dependent cell invasion. Traffic 2011 ; 12 : 579–590. [CrossRef] [PubMed]
Weissman AM. Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol 2001 ; 2 : 169–178. [CrossRef] [PubMed]
Ozdamar B, Bose R, Barrios-Rodiles M, et al. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 2005 ; 307 : 1603–1609. [CrossRef] [PubMed]
Zhang L, Anglesio MS, O’Sullivan M, et al. The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med 2007 ; 13 : 1060–1069. [CrossRef] [PubMed]
Mettouchi A, Klein S, Guo W, et al. Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle. Mol Cell 2001 ; 8 : 115–127. [CrossRef] [PubMed]
Mack NA, Whalley HJ, Castillo-Lluva S, et al. The diverse roles of Rac signaling in tumorigenesis. Cell Cycle 2011 ; 10 : 1571–1581. [CrossRef] [PubMed]
Thomas EK, Cancelas JA, Chae HD, et al. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer Cell 2007 ; 12 : 467–478. [CrossRef] [PubMed]

[1] Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 2008 ; 9 : 690–701. [CrossRef] [PubMed]

[2] Boquet P, Lemichez E. Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis? Trends Cell Biol 2003 ; 13 : 238–246. [CrossRef] [PubMed]

[3] Torrino S, Visvikis O, Doye A, et al. The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1. Dev Cell 2011 ; 21 : 959–965. [CrossRef] [PubMed]

[4] Visvikis O, Maddugoda MP, Lemichez E. Direct modifications of Rho proteins: deconstructing GTPase regulation. Biol Cell 2010 ; 102 : 377–389. [CrossRef] [PubMed]

[5] Doye A, Mettouchi A, Bossis G, et al. CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion. Cell 2002 ; 111 : 553–564. [CrossRef] [PubMed]

[6] Visvikis O, Boyer L, Torrino S, et al. Escherichia coli producing CNF1 toxin hijacks tollip to trigger Rac1-dependent cell invasion. Traffic 2011 ; 12 : 579–590. [CrossRef] [PubMed]

[7] Weissman AM. Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol 2001 ; 2 : 169–178. [CrossRef] [PubMed]

[8] Ozdamar B, Bose R, Barrios-Rodiles M, et al. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 2005 ; 307 : 1603–1609. [CrossRef] [PubMed]

[9] Zhang L, Anglesio MS, O’Sullivan M, et al. The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med 2007 ; 13 : 1060–1069. [CrossRef] [PubMed]

[10] Mettouchi A, Klein S, Guo W, et al. Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle. Mol Cell 2001 ; 8 : 115–127. [CrossRef] [PubMed]

[11] Mack NA, Whalley HJ, Castillo-Lluva S, et al. The diverse roles of Rac signaling in tumorigenesis. Cell Cycle 2011 ; 10 : 1571–1581. [CrossRef] [PubMed]

[12] Thomas EK, Cancelas JA, Chae HD, et al. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer Cell 2007 ; 12 : 467–478. [CrossRef] [PubMed]

Prix Nobel 2012