Stéatose hépatique et stress du réticulum endoplasmique - Une histoire de phospholipides

Mélissa Flamment; Fabienne Foufelle

doi:doi:10.1051/medsci/2012281004

Accès gratuit

Numéro		Med Sci (Paris) Volume 28, Numéro 1, Janvier 2012


Page(s)		13 - 15
Section		Nouvelles
DOI		http://dx.doi.org/10.1051/medsci/2012281004
Publié en ligne		27 January 2012

Donnelly KL, Smith CI, Schwarzenberg SJ, et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005 ; 115 : 1343–1351. [PubMed]
Flamment M, Kammoun HL, Hainault I, et al. Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis. Curr Opin Lipidol 2010 ; 21 : 239–246. [CrossRef] [PubMed]
Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004 ; 306 : 457–461. [CrossRef] [PubMed]
Puri P, Mirshahi F, Cheung O, et al. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 2008 ; 134 : 568–576. [CrossRef] [PubMed]
Kammoun HL, Chabanon H, Hainault I, et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 2009 ; 119 : 1201–1215. [CrossRef] [PubMed]
Ozcan U, Yilmaz E, Ozcan L, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006 ; 313 : 1137–1140. [CrossRef] [PubMed]
Cnop M, Foufelle F, Velloso LA. Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med 2011 ; 31 août (online)
Fu S, Yang L, Li P, et al. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 2011 ; 473 : 528–531. [CrossRef] [PubMed]
Li Y, Ge M, Ciani L, et al. Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages. J Biol Chem 2004 ; 279 : 37030–37039. [CrossRef] [PubMed]
Foufelle F, Ferré P. La réponse UPR : son rôle physiologique et physiopathologique. Med Sci (Paris) 2007 ; 23 : 291–296. [CrossRef] [EDP Sciences] [PubMed]

[1] Donnelly KL, Smith CI, Schwarzenberg SJ, et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005 ; 115 : 1343–1351. [PubMed]

[2] Flamment M, Kammoun HL, Hainault I, et al. Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis. Curr Opin Lipidol 2010 ; 21 : 239–246. [CrossRef] [PubMed]

[3] Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004 ; 306 : 457–461. [CrossRef] [PubMed]

[4] Puri P, Mirshahi F, Cheung O, et al. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 2008 ; 134 : 568–576. [CrossRef] [PubMed]

[5] Kammoun HL, Chabanon H, Hainault I, et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 2009 ; 119 : 1201–1215. [CrossRef] [PubMed]

[6] Ozcan U, Yilmaz E, Ozcan L, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006 ; 313 : 1137–1140. [CrossRef] [PubMed]

[7] Cnop M, Foufelle F, Velloso LA. Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med 2011 ; 31 août (online)

[8] Fu S, Yang L, Li P, et al. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 2011 ; 473 : 528–531. [CrossRef] [PubMed]

[9] Li Y, Ge M, Ciani L, et al. Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages. J Biol Chem 2004 ; 279 : 37030–37039. [CrossRef] [PubMed]

[10] Foufelle F, Ferré P. La réponse UPR : son rôle physiologique et physiopathologique. Med Sci (Paris) 2007 ; 23 : 291–296. [CrossRef] [EDP Sciences] [PubMed]

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