Les macrophages interstitiels, gardiens de l’homéostasie immune pulmonaire

Denis Bedoret; Fabrice Bureau; Christophe J. Desmet

doi:doi:10.1051/medsci/2010263229

Accès gratuit

Numéro		Med Sci (Paris) Volume 26, Numéro 3, Mars 2010


Page(s)		229 - 231
Section		Nouvelles
DOI		http://dx.doi.org/10.1051/medsci/2010263229
Publié en ligne		15 March 2010

Bernstein DI. ABCs of asthma. Clin Cornerstone 2008; 8 : 9–25.
Willart MA, Lambrecht BN. The danger within: endogenous danger signals, atopy and asthma. Clin Exp Allergy 2009; 39 : 12–9.
Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001; 2 : 725–31.
Akbari O, Freeman GJ, Meyer EH, et al. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 2002; 8 : 1024–32.
de Heer HJ, Hammad H, Soullie T, et al. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 2004; 200 : 89–98.
Thorn J, Rylander R. Airways inflammation and glucan in a rowhouse area. Am J Respir Crit Care Med 1998; 157 : 1798–803.
Douwes J, van der Sluis B, Doekes G, et al. Fungal extracellular polysaccharides in house dust as a marker for exposure to fungi: relations with culturable fungi, reported home dampness, and respiratory symptoms. J Allergy Clin Immunol 1999; 103 : 494–500.
Douwes J, Zuidhof A, Doekes G, et al. (1-3)-beta-D-glucan and endotoxin in house dust and peak flow variability in children. Am J Respir Crit Care Med 2000; 162 : 1348–54.
Michel O, Kips J, Duchateau J, et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996; 154 : 1641–6.
Rizzo M, Naspitz C, Fernández-Caldas E, et al. Endotoxin exposure and symptoms in asthmatic children. Pedriatr Allergy Immunol 1997; 8 : 121–6.
Milton D, Johnson D, Park J. Environmental endotoxin measurement: interference and sources of variation in the Limulus assay of house dust. Am Ind Hyg Assoc J 1997; 58 : 861–7.
Braun-Fahrlander C, Riedler J, Herz U, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347 : 869–77.
Lambrecht BN, De Veerman M, Coyle AJ, et al. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J Clin Invest 2000; 106 : 551–9.
Bedoret D, Wallemacq H, Marichal T, et al. Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. J Clin Invest 2009; 119 : 3723–38.

[1] Bernstein DI. ABCs of asthma. Clin Cornerstone 2008; 8 : 9–25.

[2] Willart MA, Lambrecht BN. The danger within: endogenous danger signals, atopy and asthma. Clin Exp Allergy 2009; 39 : 12–9.

[3] Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001; 2 : 725–31.

[4] Akbari O, Freeman GJ, Meyer EH, et al. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 2002; 8 : 1024–32.

[5] de Heer HJ, Hammad H, Soullie T, et al. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 2004; 200 : 89–98.

[6] Thorn J, Rylander R. Airways inflammation and glucan in a rowhouse area. Am J Respir Crit Care Med 1998; 157 : 1798–803.

[7] Douwes J, van der Sluis B, Doekes G, et al. Fungal extracellular polysaccharides in house dust as a marker for exposure to fungi: relations with culturable fungi, reported home dampness, and respiratory symptoms. J Allergy Clin Immunol 1999; 103 : 494–500.

[8] Douwes J, Zuidhof A, Doekes G, et al. (1-3)-beta-D-glucan and endotoxin in house dust and peak flow variability in children. Am J Respir Crit Care Med 2000; 162 : 1348–54.

[9] Michel O, Kips J, Duchateau J, et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996; 154 : 1641–6.

[10] Rizzo M, Naspitz C, Fernández-Caldas E, et al. Endotoxin exposure and symptoms in asthmatic children. Pedriatr Allergy Immunol 1997; 8 : 121–6.

[11] Milton D, Johnson D, Park J. Environmental endotoxin measurement: interference and sources of variation in the Limulus assay of house dust. Am Ind Hyg Assoc J 1997; 58 : 861–7.

[12] Braun-Fahrlander C, Riedler J, Herz U, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347 : 869–77.

[13] Lambrecht BN, De Veerman M, Coyle AJ, et al. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J Clin Invest 2000; 106 : 551–9.

[14] Bedoret D, Wallemacq H, Marichal T, et al. Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. J Clin Invest 2009; 119 : 3723–38.

Prix Nobel 2012