Les multiples actions des facteurs de transcription FOXO

Anne Brunet

doi:doi:10.1051/medsci/20042010856

Accès gratuit

Numéro		Med Sci (Paris) Volume 20, Numéro 10, Octobre 2004


Page(s)		856 - 859
Section		Nouvelles
DOI		http://dx.doi.org/10.1051/medsci/20042010856
Publié en ligne		15 October 2004

Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96 : 857–68.
Tran H, Brunet A, Griffith EC, Greenberg ME. The many forks in FOXO’s road. Science STKE 2003; RE5.
Lin K, Dorman JB, Rodan A, Kenyon C. Daf-16 : an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 1997; 278 : 1319–22.
Giannakou ME, Goss M, Junger MA, et al. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 2004; 305 : 361.
Hwangbo DS, Gersham B, Tu MP, et al. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 2004; 429 : 562–6.
Holzenberger M, Dupont J, Ducos B, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003; 421 : 182–7.
Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003; 299 : 572–4.
Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004; 303 : 2011–5.
Motta MC, Divecha N, Lemieux M, et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 2004; 116 : 551–63.
Van Der Horst A, Tertoolen LG, De Vries-Smits LM, et al. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1. J Biol Chem 2004; 279 : 28873–9.
Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev 2000; 14 : 1021–6.
Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425 : 191–6.
Vaziri H, Dessain SK, Ng Eaton E, et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 2001; 107 : 149–59.
Luo J, Nikolaev AY, Imai S, et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 2001; 107 : 137–48.
Antebi A. Tipping the balance toward longevity. Dev Cell 2004; 6 : 315–6.
Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001; 410 : 227–30.
Hu MC, Lee DF, Xia W, et al. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004; 117 : 225–37.
Seoane J, Le HV, Shen L, et al. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 2004; 117 : 211–23.
Sandri M, Sandri C, Gilbert A, et al. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 2004; 117 : 399–412.
Stitt TN, Drujan D, Clarke BA, et al. The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell 2004; 14 : 395–403.
Castrillon DH, Miao L, Kollipara R, et al. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 2003; 301 : 215–8.
Hosaka T, Biggs WH 3rd, Tieu D, et al. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci USA 2004; 101 : 2975–80.

[1] Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96 : 857–68.

[2] Tran H, Brunet A, Griffith EC, Greenberg ME. The many forks in FOXO’s road. Science STKE 2003; RE5.

[3] Lin K, Dorman JB, Rodan A, Kenyon C. Daf-16 : an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 1997; 278 : 1319–22.

[4] Giannakou ME, Goss M, Junger MA, et al. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 2004; 305 : 361.

[5] Hwangbo DS, Gersham B, Tu MP, et al. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 2004; 429 : 562–6.

[6] Holzenberger M, Dupont J, Ducos B, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003; 421 : 182–7.

[7] Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003; 299 : 572–4.

[8] Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004; 303 : 2011–5.

[9] Motta MC, Divecha N, Lemieux M, et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 2004; 116 : 551–63.

[10] Van Der Horst A, Tertoolen LG, De Vries-Smits LM, et al. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1. J Biol Chem 2004; 279 : 28873–9.

[11] Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev 2000; 14 : 1021–6.

[12] Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425 : 191–6.

[13] Vaziri H, Dessain SK, Ng Eaton E, et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 2001; 107 : 149–59.

[14] Luo J, Nikolaev AY, Imai S, et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 2001; 107 : 137–48.

[15] Antebi A. Tipping the balance toward longevity. Dev Cell 2004; 6 : 315–6.

[16] Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001; 410 : 227–30.

[17] Hu MC, Lee DF, Xia W, et al. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004; 117 : 225–37.

[18] Seoane J, Le HV, Shen L, et al. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 2004; 117 : 211–23.

[19] Sandri M, Sandri C, Gilbert A, et al. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 2004; 117 : 399–412.

[20] Stitt TN, Drujan D, Clarke BA, et al. The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell 2004; 14 : 395–403.

[21] Castrillon DH, Miao L, Kollipara R, et al. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 2003; 301 : 215–8.

[22] Hosaka T, Biggs WH 3rd, Tieu D, et al. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci USA 2004; 101 : 2975–80.

Prix Nobel 2012